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Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma

Oncogene volume 18, pages 7063–7069 (1999)Cite this article

Abstract

Genomic imprinting is an inherited epigenetic phenomenon that results in parental – origin – specific gene expression in somatic cells. Relaxation or loss of this feature in certain genes has been demonstrated in several pediatric and adult neoplasms, suggesting an association with tumorigenesis. We analysed 64 primary untreated head and neck squamous carcinoma for the loss of imprinting in the IGF2 and H19 genes to determine the implications of this alteration in the development and progression of these tumors. Forty-nine (77%) of the 64 tumors were informative for imprinting analyses of these genes. IGF2 and H19 were imprinted in all normal squamous epithelium examined. Twelve (37.5%) of 32 tumors informative for H19 and 11 (40.7%) of 27 tumors informative for IGF2 manifested loss of imprinting. Ten tumors were informative for both genes, of which four maintained the constitutional imprinting and six showed loss of imprinting at either H19 or IGF2. These data suggest that loss of imprinting at the IGF2 and H19 loci play a role in the oncogenesis of head and neck carcinoma.

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Acknowledgements

We are grateful to Dr Andrew Feinberg for his constructive suggestions and review of the manuscript and to Sue Martinez for typing the manuscript. This work is supported by the Oral Cancer Center Excellence Grant #1P50DE11906-01.

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Authors and Affiliations

  1. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, TX, USA

    Adel K El-Naggar & Syeling Lai

  2. Department of Biomarthematics, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, TX, USA

    Susan A Tucker

  3. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, TX, USA

    Gary L Clayman & Helmuth Goepfert

  4. Department of Thoracic Head and Neck, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, TX, USA

    Waun Ki Hong

  5. Department of Experimental Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, TX, USA

    Vicki Huff

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  1. Adel K El-Naggar
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El-Naggar, A., Lai, S., Tucker, S. et al. Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma. Oncogene 18, 7063–7069 (1999). https://doi.org/10.1038/sj.onc.1203192

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