Figure 1 | Oncogene

Figure 1

From: NF-κB as a primary regulator of the stress response

Figure 1

Schematic representation of components of the NF-κB signal transduction pathway leading from the TNF and IL-1 receptors. A number of signal transduction proteins have been identified as associated with these receptors, including TNF-receptor associated factors 2 and 6 [TRAF2 and 6], death domain-containing proteins [TRADD and FADD], kinases associated with the IL-1 receptor [IRAK1 and 2, and MYD88]. Other proteins, such as ring finger interacting protein [RIP] have been identified based on their ability to interact with several of these proteins. Signals emanating from the TNF and IL-1 receptors activate members of the MEKK-related family, including NIK and MAKK1. These proteins are involved in activation of IKK1 and IKK2, the IκB kinase components of the IKK signalsome. These kinases phosphorylate members of the IkB family at specific serines within their N-termini, leading to site-specific ubiquitination and degradation by the 26S proteosome

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