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Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival

Oncogene volume 18, pages 6129–6134 (1999)Cite this article

Abstract

The details of nuclear transport mechanisms are emerging rapidly, largely through work with model organisms. Here, we briefly describe these advances, with an emphasis on the remaining challenges. We then address the nuclear transport of some high profile cellular regulators, including p53 and the proto-oncogene PKB/Akt. We discuss the mechanisms that contribute to the differential subcellular localization of these proteins. Finally, we analyse the provocative patterns that emerge from our overview.

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  1. Department of Cancer Biology, The Dana-Farber Cancer Institute, 44 Binney Street, Boston, 02115, Massachusetts, MA, USA

    Paul Ferrigno & Pamela A Silver

  2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

    Paul Ferrigno & Pamela A Silver

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Ferrigno, P., Silver, P. Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival. Oncogene 18, 6129–6134 (1999). https://doi.org/10.1038/sj.onc.1203132

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