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Loss of heterozygosity at the proximal-mid part of mouse chromosome 4 defines two novel tumor suppressor gene loci in T-cell lymphomas

Oncogene volume 18, pages 4166–4169 (1999)Cite this article

Abstract

Recent studies in our laboratory reported frequent loss of heterozygosity (LOH) on mouse chromosome 4 in T-cell lymphomas, identifying three candidate tumor suppressor regions (TLSR1 – 3). To determine the possible existence of other tumor suppressor gene loci on the proximal-mid part of chromosome 4 and to clarify whether the p16INK4a (α and β) and p15INK4b genes are the inactivation targets of deletion at TLSR1, we have tested 73 γ-radiation-induced T-cell lymphomas of F1 hybrid mice by LOH analysis. Frequent LOH was found at the INK4a and INK4b loci and the surrounding markers D4Mit77, D4Mit245 and D4Wsm1. In addition, we identified two distinct regions of significant allelic losses in the proximal-mid part of chromosome 4, defined by the markers D4Mit116 (TLSR4) and D4Mit21 (TLSR5). Taken together, this evidence and our previous data indicate the existence of at least five different candidate sites for tumor suppressor genes on chromosome 4, thus revealing a main role for this chromosome in the development of mouse T-cell lymphomas.

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Acknowledgements

This work was supported by grants from the Ministerio de Educación y Ciencia of Spain (PM96/001), the Fundación Ramón Areces and the Comunidad Autónoma de Madrid (08.1/0009/1997). We thank Michel Herranz for his technical support.

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  1. Departamento de Biología, Laboratorio de Genética Molecular Humana, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049-Madrid, Spain

    Bárbara Meléndez, Javier Santos & José Fernández-Piqueras

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  1. Bárbara Meléndez
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  2. Javier Santos
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  3. José Fernández-Piqueras
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Meléndez, B., Santos, J. & Fernández-Piqueras, J. Loss of heterozygosity at the proximal-mid part of mouse chromosome 4 defines two novel tumor suppressor gene loci in T-cell lymphomas. Oncogene 18, 4166–4169 (1999). https://doi.org/10.1038/sj.onc.1202826

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