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Myb binding proteins: regulators and cohorts in transformation

Oncogene volume 18, pages 3039–3046 (1999)Cite this article

Abstract

The c-Myb and v-Myb proteins are transcription factors that regulate cell proliferation and differentiation. Both Myb proteins have been shown to interact with a number of cellular proteins, some of which are transcription factors that cooperate to activate specific promoters, while others regulate the transcriptional activity of Myb in specific contexts. By comparing and analysing the types of proteins that bind Myb, and the conserved domains of Myb that interact with other proteins, conclusions can be drawn regarding the role of specific partner proteins in the regulation of gene expression, cell proliferation and disease.

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Acknowledgements

The author thanks the present and past members of his laboratory as well his colleagues Achim Leutz, Kathy Weston and Angela Wandinger-Ness for many useful discussions and comments on the manuscript. SA Ness is supported in part by NIH grant CA580443 as well as by an institutional award from the Howard Hughes Medical Institute.

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  1. Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud NE, Albuquerque, NM 87131, New Mexico, USA

    Scott A Ness

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Ness, S. Myb binding proteins: regulators and cohorts in transformation. Oncogene 18, 3039–3046 (1999). https://doi.org/10.1038/sj.onc.1202726

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