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Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease

Oncogene volume 18, pages 3902–3904 (1999)Cite this article

Abstract

A germline sequence alteration at codon 1307 of the APC gene (I1307K) has been reported in 6 – 7% of the Ashkenazi Jewish population in the United States. This alteration is believed to predispose the APC gene to a secondary mutation at the same locus, resulting in an increased risk of colorectal carcinoma. There is an increased risk of colorectal carcinoma in patients with inflammatory bowel disease (IBD), a relatively large proportion of whom are Ashkenazi Jews. We therefore sought to determine whether the I1307K sequence variant occurred in the germline DNA of IBD patients. To our surprise, we found this sequence in only two of 267 patients with IBD (0.7%), occurring in only 1.5% of Jewish IBD patients. The I1307K sequence variant was not found in 67 patients with esophageal cancer, 53 patients with gastric carcinoma (13 MSI-H and 44 MSI-negative), or ten patients with sporadic MSI-H colon cancer. These findings suggest that the I1307K sequence is relatively rare in the germline of Jewish as well as non-Jewish IBD patients. It does not appear to contribute to the increased colorectal cancer risk present in these patients.

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Abbreviations

MSI-H:

microsatellite instability-high

MSI-L:

microsatellite instability-low

MSI-negative:

microsatellite instability-negative

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Acknowledgements

The authors thank Ms Crystal Lewis for ascertaining ethnicity of the IBD patients; and Drs Laurence S Magder and J Richard Hebel of the Department of Epidemiology and Preventive Medicine for assistance with statistical calculations. Supported by USPHS grants CA77057, CA78843, DK47717, CA67497 and DK53620 and the Office of Medical Research, Department of Veterans Affairs.

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Authors and Affiliations

  1. Department of Medicine, Gastroenterology Division, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, 21201, Maryland, USA

    Jing Yin, Rhonda F Souza, Tongtong Zou, Dehe Kong, Suna Wang, Kara N Smolinski, John M Abraham, A Steven Fleisher & Stephen J Meltzer

  2. Greenebaum Cancer Center, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, 21201, Maryland, USA

    Stephen J Meltzer

  3. Molecular Biology Graduate Program, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, 21201, Maryland, USA

    Kara N Smolinski & Stephen J Meltzer

  4. Department of Pathology, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, 21201, Maryland, USA

    Dehe Kong & Stephen J Meltzer

  5. Department of Pathology, Mt. Sinai School of Medicine of New York University, New York, NY, USA

    Noam Harpaz, Anatoly L Leytin & Neil S Medalie

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  1. Jing Yin
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  2. Noam Harpaz
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Yin, J., Harpaz, N., Souza, R. et al. Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease. Oncogene 18, 3902–3904 (1999). https://doi.org/10.1038/sj.onc.1202638

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