Abstract
c-src was first isolated as the normal cellular homologue of v-src, the transforming gene of Rous Sarcoma virus (). As the first proto-oncogene described and one of the first molecules demonstrated to have tyrosine kinase activity, Src has provided a prototype for understanding signal transduction involving tyrosine phosphorylation. Comparison between c-src and activated or transforming mutants of Src including v-src, combined with recent data on the structure of Src family kinases has provided new insight into their regulation. In this review, I will discuss the function of the various domains of Src in light of these mutational and structural studies.
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Schwartzberg, P. The many faces of Src: multiple functions of a prototypical tyrosine kinase. Oncogene 17, 1463–1468 (1998). https://doi.org/10.1038/sj.onc.1202176
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DOI: https://doi.org/10.1038/sj.onc.1202176
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