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Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

Oncogene volume 16, pages 2557–2564 (1998)Cite this article

Abstract

Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. CIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six (one with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

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  1. MF Evans, J Koreth, CJ Bakkenist, CS Herrington & JO'D McGee

    Present address: Department of Pathology, Duncan Building, Royal Liverpool University Hospital, Daulby Street, Liverpool, L69 3BX, Merseyside, UK

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  1. Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    MF Evans & CS Herrington

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  1. MF Evans
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  2. J Koreth
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  3. CJ Bakkenist
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  4. CS Herrington
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  5. JO'D McGee
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Evans, M., Koreth, J., Bakkenist, C. et al. Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia. Oncogene 16, 2557–2564 (1998). https://doi.org/10.1038/sj.onc.1202039

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  • DOI: https://doi.org/10.1038/sj.onc.1202039

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