Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The TEL gene products: nuclear phosphoproteins with DNA binding properties

Abstract

The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first in-frame ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Olivier A Bernard.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Poirel, H., Oury, C., Carron, C. et al. The TEL gene products: nuclear phosphoproteins with DNA binding properties. Oncogene 14, 349–357 (1997). https://doi.org/10.1038/sj.onc.1200829

Download citation

Keywords

  • TEL
  • ETS
  • translocation
  • transcription factor
  • leukemia
  • translocation

Further reading

Search

Quick links