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The Action of Strychnine on the Cerebellar Cortex


THAT strychnine has a stimulating action on the cerebellar cortex was shown by me a few years ago—(Science, 51, 413, 1920). On the application of strychnine to the surface of the lobulus ansiformis or cerebellar hemisphere the motor manifestations consist in increased tonus, together with clonus, affecting particularly the ipsilateral hindleg, though affecting also, to some extent, the forelegs and the contralateral hindleg. My positive results obtained with strychnine in the cat agree with those of Shimazono (Arch. f. mik. Anat., 80, 397, 1912), who observed an ipsilateral increase of tonus after applying strychnine to the cerebellar cortex in the pigeon.

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MILLER, F. The Action of Strychnine on the Cerebellar Cortex. Nature 117, 486–487 (1926).

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