Table 1 Summary of adverse events reported with immediate-release nifedipine

From: The dangers of immediate-release nifedipine in the emergency treatment of hypertension

Study population Nifedipine preparation Adverse events Reference
166 hypertensive paediatric patients Variable Change in neurological status 3.6% (33% in those with acute CNS injury)
Hypotension 1.2%
Oxygen desaturation 9.6%
93 hypertensive patients, aged >65 years, without coronary artery disease 5 mg sublingual Myocardial ischaemia on ECG 7.5% (10.9% in those with LVH)
Angina-like precordial tightness 2.2%
13 patients in the emergency department with a hypertensive crisis 10 mg sublingual Reduction in middle cerebral artery flow velocity by 7.2% 8
30 adult patients with a hypertensive crisis 10 mg oral Angina pectoris with ECG changes 6.7%
Rebound hypertension 13.3%
32 patients with pregnancy-induced hypertension 10–20 mg t.d.s. oral 34% increase in postpartum blood loss compared to controls 10
14 asymptomatic patients with hypertensive urgency Single dose of 20 mg, short-acting Transient cerebrovascular ischaemic attack 7.1% 11
  1. Abbreviations: CNS, central nervous system; ECG, electrocardiogram; LVH, left ventricular hypertophy