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Association of novel promoter single nucleotide polymorphisms in vasopressin V1a receptor gene with essential hypertension in nonobese Japanese

Journal of Human Hypertension volume 21, pages 825–827 (2007)Cite this article

We studied the association between four novel single nucleotide polymorphisms (SNPs) in the promoter region of V1aR gene and essential hypertension in 620 Japanese subjects (365 hypertensives and 255 healthy). A significant association was found between one of the genotypes and alleles at SNP −6951 and hypertension in a subsample of nonobese individuals. This association demonstrated an independent risk for nonobese hypertension.

Arginine vasopressin (AVP) plays an important role in cardiovascular regulation. AVP acts on V1a receptor (V1aR) to increase vascular tone and baroreceptor sensitivity.1, 2 Extensive studies have been made in the search for the genetic basis of essential hypertension.3 V1aR gene also represents a reasonable candidate for the study of its involvement in human essential hypertension. Recently, it has become evident that in clinically defined subtypes of hypertension, obesity-associated hypertension may be genetically distinct from hypertension in nonobese individuals.4 Since an investigation of clinically defined subsets of hypertension may facilitate the search for their specific genes, we explored whether the identified four novel single nucleotide polymorphisms (SNPs) of V1aR gene (−6951G/A, −4112A/T, −3860T/C and −242C/T) could be associated with either obesity-associated hypertension or hypertension in nonobese individuals.

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Acknowledgements

Support from the Ministry of Education, Science, Sports and Culture, Japan (Grant-in-Aid for Scientific Research No. 15590477 and No. 17590482).

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Authors and Affiliations

  1. Department of Laboratory Medicine, Hirosaki University School of Medicine, Aomori, Japan

    K N Hasan, M Shoji & M Yasujima

  2. Department of Pharmacodynamics, Meiji Pharmaceutical University, Tokyo, Japan

    M Shoji

  3. Department of Clinical Laboratory, Hirosaki University Hospital, Aomori, Japan

    K Sugimoto, S Tsutaya, E Matsuda & R Kudo

  4. Department of Social Medicine, Hirosaki University School of Medicine, Aomori, Japan

    S Nakaji

  5. Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan

    T Suda

Authors
  1. K N Hasan
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  2. M Shoji
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  3. K Sugimoto
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  4. S Tsutaya
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  5. E Matsuda
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  6. R Kudo
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  7. S Nakaji
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  8. T Suda
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  9. M Yasujima
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Corresponding author

Correspondence to M Shoji.

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Supplementary Information accompanies the paper on the Journal of Human Hypertension website (http://www.nature.com/jhh).

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Hasan, K., Shoji, M., Sugimoto, K. et al. Association of novel promoter single nucleotide polymorphisms in vasopressin V1a receptor gene with essential hypertension in nonobese Japanese. J Hum Hypertens 21, 825–827 (2007). https://doi.org/10.1038/sj.jhh.1002227

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