Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Persistence and adherence with antihypertensive drug therapy in a German sickness fund population

Journal of Human Hypertension volume 21, pages 744–746 (2007)Cite this article

The objective of this retrospective cohort study was to examine persistence and adherence (compliance) with newly initiated antihypertensive therapy in the real-life setting of a German sickness fund. Persistence was highest after an index prescription for angiotensin receptor blockers (ARBs) (52.7%), followed by angiotensin-converting enzyme (ACE) inhibitors (34.5%), calcium channel blockers (CCBs; 34.4%), diuretics (26.0%) and β -blockers (13.6%).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289: 2560–2572.

    Article  CAS  PubMed Central  Google Scholar 

  2. Psaty BM, Smith NL, Siscovick DS, Koepsell TD, Weiss NS, Heckbert SR et al. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. JAMA 1997; 277: 739–745.

    Article  CAS  Google Scholar 

  3. Turnbull F, Blood Pressure Lowering Treatment Trialists’ Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet 2003; 362: 1527–1535.

    Article  CAS  Google Scholar 

  4. World Health Organization. Adherence to Long-term Therapies. Evidence for Action. World Health Organization: Geneva, 2003.

  5. Steiner JF, Koepsell TD, Fihn SD, Inui TS . A general method of compliance assessment using centralized pharmacy records: description and validation. Med Care 1988; 26: 814–823.

    Article  CAS  PubMed Central  Google Scholar 

  6. Conlin PR, Gerth WC, Fox J, Roehm JB, Boccuzi SJ . Four year persistence patterns among patients initiating therapy with the angiotensin II receptor antagonist losartan versus other antihypertensive drug classes. Clin Ther 2006; 23: 1999–2010.

    Article  Google Scholar 

  7. Degli Esposti E, Sturani A, Di Martino M, Falasca P, Novi MV, Baio G et al. Long-term persistence with antihypertensive drugs in new patients. J Hum Hypertens 2002; 16: 439–444.

    Article  CAS  PubMed Central  Google Scholar 

  8. Wannemacher AJ, Schepers GP, Townsend KA . Antihypertensive medication compliance in a Veterans’ Affairs healthcare system. Ann Pharmacother 2002; 36: 986–991.

    Article  PubMed Central  Google Scholar 

  9. Hasford J, Mimran A, Simons WR . A population-based European cohort study of persistence in newly diagnosed hypertensive patients. J Hum Hypertens 2002; 16: 569–575.

    Article  CAS  Google Scholar 

  10. Wogen J, Kreilick CA, Livornese RC, Yokoyama K, Frech F . Patient adherence with amlodipine, lisinopril, or valsartan therapy in a usual-care setting. J Manag Care Pharm 2003; 9: 424–429.

    PubMed  Google Scholar 

  11. Erkens JA, Panneman MM, Klungel OH, van den Boom G, Prescott MF, Herings RM . Differences in antihypertensive drug persistence associated with drug class and gender: a PHARMO study. Pharmacoepidemiol Drug Saf 2005; 14: 795–803.

    Article  Google Scholar 

  12. WHO Collaborating Centre for Drug Statistics Methodology. http://www.whocc.no/atcddd/.

Download references

Author information

Authors and Affiliations

  1. IGES – Institute for Healthcare and Social Research, Berlin, Germany

    A Höer, H Gothe, G Schiffhorst & B Häussler

  2. Novartis Pharmaceutical Corporation, East Hanover, NJ, USA

    Z M Khan

  3. Novartis Pharma AG, Basel, Switzerland

    G Vincze

Authors
  1. A Höer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H Gothe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Z M Khan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G Schiffhorst
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G Vincze
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B Häussler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Höer.

Additional information

Supplementary Information accompanies the paper on the Journal of Human Hypertension website (http://www.nature.com/jhh)

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Höer, A., Gothe, H., Khan, Z. et al. Persistence and adherence with antihypertensive drug therapy in a German sickness fund population. J Hum Hypertens 21, 744–746 (2007). https://doi.org/10.1038/sj.jhh.1002223

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jhh.1002223

This article is cited by

Search

Advanced search

Quick links