Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Predictive value of heart-type fatty acid-binding protein for left ventricular remodelling and clinical outcome of hypertensive patients with mild-to-moderate aortic valve diseases

Journal of Human Hypertension volume 21, pages 551–557 (2007)Cite this article

Abstract

Heart-type fatty acid-binding protein (H-FABP), a marker of acute myocardial infarction and a soluble cytosolic protein, may be released following left ventricular remodelling in cardiac overloaded hearts caused by hypertension, aortic regurgitation (AR) or aortic stenosis (AS). Our aim was to investigate if H-FABP levels are associated with left ventricular remodelling and clinical outcome in hypertensive patients with AR or AS. H-FABP and brain natriuretic peptide (BNP) were measured, glomerular filtration rate (GFR) was estimated using the modification of diet in renal disease (MDRD) equation, and left ventricular dimension at systole corrected for body surface area (LVDs/BSA) and relative wall thickness (RWT) were determined by echocardiography in hypertensive patients with mild-to-moderate AR (n=78), those with mild-to-moderate AS (n=73) and those without valvular heart diseases (HT) (n=50). H-FABP levels were significantly higher in AR (4.9±3 ng/ml) and in AS (4.5±3) than in HT (3.4±1) and BNP (65±73 pg/ml, 76±75, 35±22). H-FABP correlated with LVDs/BSA in AR (β=0.23, P<0.05), and RWT in AS (β=0.18, P<0.05) after adjustment for age, gender and all the other variables. AS and AR patients were prospectively followed up for cardiac events during 34±19 months. A multivariate Cox hazard analysis indicated H-FABP was an independent predictor of outcome both in AR (relative risk (RR)=7.61, 95% CI=2.39–25.3) and AS (RR=13.6, 95% CI=3.27–66.9). H-FABP, associated with left ventricular remodelling, is useful in predicting clinical outcome in hypertensive patients with mild-to-moderate aortic valve diseases.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Glatz JF, van der Vusse GJ, Simoons ML, Kragten JA, van Dieijen-Visser MP, Hermens WT . Fatty acid-binding protein and the early detection of acute myocardial infarction. Clin Chim Acta 1998; 272: 87–92.

    Article  CAS  Google Scholar 

  2. Setsuta K, Seino Y, Ogawa T, Arao M, Miyatake Y, Takano T . Use of cytosolic and myofibril markers in the detection of ongoing myocardial damage in patients with chronic heart failure. Am J Med 2002; 113: 717–722.

    Article  CAS  Google Scholar 

  3. Pelsers MM, Hermens WT, Glatz JF . Fatty acid-binding proteins as plasma markers of tissue injury. Clin Chim Acta 2005; 352: 15–35.

    Article  CAS  Google Scholar 

  4. Rosenhek R, Klaar U, Schemper M, Scholten C, Heger M, Gabriel H et al. Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography. Eur Heart J 2004; 25: 199–205.

    Article  Google Scholar 

  5. Antonini-Canterin F, Huang G, Cervesato E, Faggiano P, Pavan D, Piazza R et al. Symptomatic aortic stenosis: does systemic hypertension play an additional role? Hypertension 2003; 41: 1268–1272.

    Article  CAS  Google Scholar 

  6. Kontos J, Papademetriou V, Wachtell K, Palmieri V, Liu JE, Gerdts E et al. Impact of valvular regurgitation on left ventricular geometry and function in hypertensive patients with left ventricular hypertrophy: the LIFE study. J Hum Hypertens 2004; 18: 431–436.

    Article  CAS  Google Scholar 

  7. Cohn JN, Ferrari R, Sharpe N . Cardiac remodeling – concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 2000; 35: 569–582.

    Article  CAS  Google Scholar 

  8. Carabello BA . Concentric versus eccentric remodeling. J Card Fail 2002; 8: S258–S263.

    Article  Google Scholar 

  9. Rossi A, Tomaino M, Golia G, Anselmi M, Fuca G, Zardini P . Echocardiographic prediction of clinical outcome in medically treated patients with aortic stenosis. Am Heart J 2000; 140: 766–771.

    Article  CAS  Google Scholar 

  10. Komamura K, Sasaki T, Hanatani A, Kim J, Hashimura K, Ishida Y et al. Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. Heart 2006; 92: 615–618.

    Article  CAS  Google Scholar 

  11. Morioka N, Shigematsu Y, Hamada M, Higaki J . Circulating levels of heart-type fatty acid-binding protein and its relation to thallium-201 perfusion defects in patients with hypertrophic cardiomyopathy. Am J Cardiol 2005; 95: 1334–1337.

    Article  CAS  Google Scholar 

  12. Ricchiuti V, Zhang J, Apple FS . Cardiac troponin I and T alterations in hearts with severe left ventricular remodeling. Clin Chem 1997; 43: 990–995.

    CAS  PubMed  Google Scholar 

  13. Azzazy HM, Pelsers MM, Christenson RH . Unbound free fatty acids and heart-type fatty acid-binding protein: diagnostic assays and clinical applications. Clin Chem 2006; 52: 19–29.

    Article  CAS  Google Scholar 

  14. Fischer TA, McNeil PL, Khakee R, Finn P, Kelly RA, Pfeffer MA et al. Cardiac myocyte membrane wounding in the abruptly pressure-overloaded rat heart under high wall stress. Hypertension 1997; 30: 1041–1046.

    Article  CAS  Google Scholar 

  15. Bekeredjian R, Grayburn PA . Valvular heart disease: aortic regurgitation. Circulation 2005; 112: 125–134.

    Article  Google Scholar 

  16. Gerber IL, Legget ME, West TM, Richards AM, Stewart RA . Usefulness of serial measurement of N-terminal pro-brain natriuretic peptide plasma levels in asymptomatic patients with aortic stenosis to predict symptomatic deterioration. Am J Cardiol 2005; 95: 898–901.

    Article  CAS  Google Scholar 

  17. Gerber IL, Stewart RA, Legget ME, West TM, French RL, Sutton TM et al. Increased plasma natriuretic peptide levels reflect symptom onset in aortic stenosis. Circulation 2003; 107: 1884–1890.

    Article  Google Scholar 

  18. Nessmith MG, Fukuta H, Brucks S, Little WC . Usefulness of an elevated B-type natriuretic peptide in predicting survival in patients with aortic stenosis treated without surgery. Am J Cardiol 2005; 96: 1445–1448.

    Article  CAS  Google Scholar 

  19. Weber M, Arnold R, Rau M, Elsaesser A, Brandt R, Mitrovic V et al. Relation of N-terminal pro B-type natriuretic peptide to progression of aortic valve disease. Eur Heart J 2005; 26: 1023–1030.

    Article  CAS  Google Scholar 

  20. Lim P, Monin JL, Monchi M, Garot J, Pasquet A, Hittinger L et al. Predictors of outcome in patients with severe aortic stenosis and normal left ventricular function: role of B-type natriuretic peptide. Eur Heart J 2004; 25: 2048–2053.

    Article  CAS  Google Scholar 

  21. Hillege HL, Girbes AR, de Kam PJ, Boomsma F, de Zeeuw D, Charlesworth A et al. Renal function, neurohormonal activation, and survival in patients with chronic heart failure. Circulation 2000; 102: 203–210.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, Mitsubishi Nagoya Hospital, Nagoya, Japan

    M Iida & M Yamazaki

  2. Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

    H Honjo, I Kodama & k Kamiya

Authors
  1. M Iida
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Yamazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H Honjo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I Kodama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. k Kamiya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M Iida.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iida, M., Yamazaki, M., Honjo, H. et al. Predictive value of heart-type fatty acid-binding protein for left ventricular remodelling and clinical outcome of hypertensive patients with mild-to-moderate aortic valve diseases. J Hum Hypertens 21, 551–557 (2007). https://doi.org/10.1038/sj.jhh.1002195

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jhh.1002195

Keywords

This article is cited by

Search

Advanced search

Quick links