Abstract
Elevated blood pressure (BP) in children is an early risk factor for cardiovascular disease and is positively associated with body mass index (BMI). However, BMI does not distinguish between fat and lean masses, and the relationship of BP in children to different elements of body composition is not well established. BP, BMI and body composition were measured in 6863 children enrolled in the Avon Longitudinal Study of Parents and Children. Fat mass, lean mass and trunk fat were assessed using dual-energy X-ray absorptiometry. After full adjustment for confounders, total body fat and BMI were positively associated with systolic blood pressure (SBP) (β=3.29, 95% confidence interval CI 3.02, 3.57 mm Hg/standard deviation (s.d.) and β=3.97, 95% CI 3.73, 4.21 mm Hg/s.d., respectively) and diastolic blood pressure (DBP) (β=1.26, 95% CI 1.05, 1.46 mm Hg/s.d. and β=1.37, 95% CI 1.19, 1.54 mm Hg/s.d., respectively). SBP was also positively associated with lean mass (β=3.38, 95% CI 2.95, 3.81 mm Hg/s.d.), and weakly associated with trunk fat (β=1.42, 95% CI −0.06, 2.90 mm Hg/s.d., independent of total fat mass), which was robust in girls only. The association between lean mass and SBP remained even after accounting for fat mass. SBP in 9-year-old children is independently associated with fat mass and lean mass and, to a lesser extent, trunk fat in girls. In this analysis, because both fat and lean masses are associated with BP, BMI predicts BP at least as well as these components of body composition.
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Acknowledgements
We thank to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laborotary technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. The UK Medical Research Council, the Wellcome Trust and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and Marie-Jo Brion and Andy Ness will serve as guarantors for the contents of this paper. Marie-Jo Brion is jointly funded by the Overseas Research Students Awards Scheme and the University of Bristol. None of the authors had any financial or personal interest in any of the companies or organizations sponsoring this research. Contents of this article represent the views of the authors and not necessarily those of the funding bodies.
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Brion, M., Ness, A., Davey Smith, G. et al. Association between body composition and blood pressure in a contemporary cohort of 9-year-old children. J Hum Hypertens 21, 283–290 (2007). https://doi.org/10.1038/sj.jhh.1002152
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DOI: https://doi.org/10.1038/sj.jhh.1002152
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