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The relation between serum level of amioterminal propeptide of type I procollagen and diastolic dysfunction in hypertensive patients without diabetes mellitus: a pilot study

Journal of Human Hypertension volume 20, pages 964–967 (2006)Cite this article

In the present study, we assessed the relation between diastolic dysfunction (measured by technetium-99m radionuclide ventriculography) and serum levels of myocardial fibrosis markers (amino-terminal propeptides of type I and III procollagen; PINP and PIIINP) in hypertensive patients without diabetes mellitus. Patients with abnormal PINP level (>53  μ g/l) had significantly lower left ventricular peak filling rate (PFR) and shorter time to PFR than patients with normal PINP level (⩽53  μ g/l). Elevated serum PINP level reflected diastolic dysfunction in hypertensive patients without diabetes.

Arterial hypertension stimulates both myocardial procollagen gene expression and collagen synthesis. The excess deposit of myocardial collagen content results in myocardial stiffness and diastolic dysfunction.1, 2 The conventional methods to evaluate diastolic function are Doppler echocardiography and radionuclide ventriculography. However, their uses are limited by cost considering the large number of hypertensive patients. Therefore, biochemical methods for detecting diastolic dysfunction are required. Recently, non-invasive evaluation of myocardial fibrosis by using serological markers of collagen I and III turnover has been reported. These markers provide valuable diagnostic information on the extent of myocardial fibrosis.2, 3, 4 We hypothesized that serological markers of collagen turnover can offer additional values for evaluating diastolic dysfunction in hypertensive patients. Therefore, we conducted this prospective study to evaluate the relation between serum markers of myocardial fibrosis and diastolic dysfunction.

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Acknowledgements

This study was supported by the National Science Council, Taipei, Taiwan (grant NSC 92-2314-B-002-322-).

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Authors and Affiliations

  1. Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan

    Y H Lin

  2. Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

    Y H Lin, Y L Ho & P J Huang

  3. Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei, Taiwan

    Y W Chiu

  4. Department of Nuclear Medicine, Far-Eastern Memorial Hospital, Taipei, Taiwan

    Y C Shiau

  5. Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

    R F Yen & P J Huang

  6. Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

    I J Tsai

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  1. Y H Lin
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Correspondence to Y L Ho.

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Lin, Y., Chiu, Y., Shiau, Y. et al. The relation between serum level of amioterminal propeptide of type I procollagen and diastolic dysfunction in hypertensive patients without diabetes mellitus: a pilot study. J Hum Hypertens 20, 964–967 (2006). https://doi.org/10.1038/sj.jhh.1002092

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