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Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population

Abstract

It has been reported that the mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism, also called NADH dehydrogenase subunit 2-237 methionine/leucine (ND2-237 Met/Leu) polymorphism, may be associated with longevity in Japanese individuals, and that the mt5178A genotype may have an antiatherogenic influence. To determine whether mt5178 A/C polymorphism influences blood pressure, we genotyped 412 healthy Japanese individuals and performed a cross-sectional study investigating the relationship between genotype and blood pressure. In women with mt5178A, the mean diastolic blood pressure was higher than in those with mt5178C by 3.2 mmHg (P=0.040). In men, no statistically significant difference in systolic or diastolic blood pressure was observed between mt5178 A/C genotypes. However, a significant correlation between mt5178 A/C genotypes and the effects of habitual drinking on blood pressure was found. After adjustment for several factors, in men carrying mt5178C, both systolic and diastolic blood pressure were significantly higher in daily drinkers than in occasional (P=0.002 and 0.002, respectively) as well as nondrinkers (P<0.001 and 0.001, respectively), whereas in men carrying mt5178A, no significant differences in blood pressure were detected, irrespective of alcohol consumption. These results suggest that mt5178 A/C (=ND2-237 Met/Leu) polymorphism may influence both diastolic blood pressure in Japanese women and the blood-pressure-increasing effect of drinking in Japanese men.

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References

  1. Tanaka M et al. Mitochondrial genotype associated with longevity. Lancet 1998; 351: 185–186.

    Article  CAS  Google Scholar 

  2. De Benedictis et al. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J 1999; 13: 1532–1536.

    Article  CAS  Google Scholar 

  3. Ivanova R, Lepage V, Charron D, Schächter F . Mitochondrial genotype associated with French Caucasian centenarians. Gerontology 1998; 44: 349.

    Article  CAS  Google Scholar 

  4. Ross OA et al. Mitochondrial DNA polymorphism: its role in longevity of the Irish population. Exp Gerontol 2001; 36: 1161–1178.

    Article  CAS  Google Scholar 

  5. Niemi AK et al. Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. Hum Genet 2003; 112: 29–33.

    Article  CAS  Google Scholar 

  6. Tanaka M et al. Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis. Mech Ageing Dev 2000; 116: 65–76.

    Article  CAS  Google Scholar 

  7. Kokaze A et al. Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population. Hum Genet 2001; 109: 521–525.

    Article  CAS  Google Scholar 

  8. Matsunaga H et al. Antiatherogenic mitochondrial genotype in patients with type 2 diabetes. Diabetes Care 2001; 24: 500–503.

    Article  CAS  Google Scholar 

  9. Mukae S et al. Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. Circ J 2003; 67: 16–20.

    Article  CAS  Google Scholar 

  10. Shimokata H et al. Distribution of genetic disease-related genotypes in the National Institute for Longevity Science, Longitudinal Study of Aging (NILS-LSA). J Epidemiol 2000; 10: S46–S55.

    Article  CAS  Google Scholar 

  11. Wang D et al. Association of the mitochondrial DNA 5178 A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients. Exp Clin Endocrinol Diabetes 2001; 109: 361–364.

    Article  CAS  Google Scholar 

  12. Ohkubo R et al. Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders. J Neurol Sci 2002; 198: 31–35.

    Article  CAS  Google Scholar 

  13. Kornitzer M, Dramaix M, De Backer G . Epidemiology of risk factors for hypertension: implications for prevention and therapy. Drugs 1999; 57: 695–712.

    Article  CAS  Google Scholar 

  14. Ueshima H et al. Alcohol drinking and high blood pressure: data from a 1980 national cardiovascular survey of Japan. J Clin Epidemiol 1992; 45: 667–673.

    Article  CAS  Google Scholar 

  15. Nakanishi N et al. Risk factors for the development of hypertension: a 6-year longitudinal study of middle-aged Japanese men. J Hypertens 1998; 16: 753–759.

    Article  CAS  Google Scholar 

  16. Tsuruta M et al. Association between alcohol intake and development of hypertension in Japanese normotensive men: 12-year follow-up study. Am J Hypertens 2000; 13: 482–487.

    Article  CAS  Google Scholar 

  17. Bailey SM, Pietsch EC, Cunningham CC . Ethanol stimulates the production of reactive oxygen species at mitochondrial complex I and III. Free Radio Biol Med 1999; 27: 891–900.

    Article  CAS  Google Scholar 

  18. Inoue M et al. Cross-talk between NO and oxyradicals, a supersystem that regulates energy metabolism and survival of animals. Free Radio Res 2000; 33: 757–770.

    Article  CAS  Google Scholar 

  19. Iwai N et al. Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension. Circulation 2002; 105: 41–47.

    Article  CAS  Google Scholar 

  20. Osanai T et al. Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor. J Clin Invest 2001; 108: 1023–1030.

    Article  CAS  Google Scholar 

  21. Atlante A et al. ATP synthesis and export in heart left ventricle mitochondria from spontaneously hypertensive rat. Int J Mol Med 1998; 1: 709–716.

    CAS  PubMed  Google Scholar 

  22. Baba S et al. Blood pressure levels, related factors, and hypertension control status of Japanese and Americans. J Hum Hypertens 1991; 5: 317–332.

    CAS  PubMed  Google Scholar 

  23. Cann RL, Stoneking M, Wilson AC . Mitochondrial DNA and human evolution. Nature 1987; 325: 31–36.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (No. 14570355).

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Correspondence to A Kokaze.

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Kokaze, A., Ishikawa, M., Matsunaga, N. et al. Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population. J Hum Hypertens 18, 41–45 (2004). https://doi.org/10.1038/sj.jhh.1001632

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  • DOI: https://doi.org/10.1038/sj.jhh.1001632

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