Abstract
It has been reported that the mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism, also called NADH dehydrogenase subunit 2-237 methionine/leucine (ND2-237 Met/Leu) polymorphism, may be associated with longevity in Japanese individuals, and that the mt5178A genotype may have an antiatherogenic influence. To determine whether mt5178 A/C polymorphism influences blood pressure, we genotyped 412 healthy Japanese individuals and performed a cross-sectional study investigating the relationship between genotype and blood pressure. In women with mt5178A, the mean diastolic blood pressure was higher than in those with mt5178C by 3.2 mmHg (P=0.040). In men, no statistically significant difference in systolic or diastolic blood pressure was observed between mt5178 A/C genotypes. However, a significant correlation between mt5178 A/C genotypes and the effects of habitual drinking on blood pressure was found. After adjustment for several factors, in men carrying mt5178C, both systolic and diastolic blood pressure were significantly higher in daily drinkers than in occasional (P=0.002 and 0.002, respectively) as well as nondrinkers (P<0.001 and 0.001, respectively), whereas in men carrying mt5178A, no significant differences in blood pressure were detected, irrespective of alcohol consumption. These results suggest that mt5178 A/C (=ND2-237 Met/Leu) polymorphism may influence both diastolic blood pressure in Japanese women and the blood-pressure-increasing effect of drinking in Japanese men.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tanaka M et al. Mitochondrial genotype associated with longevity. Lancet 1998; 351: 185–186.
De Benedictis et al. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J 1999; 13: 1532–1536.
Ivanova R, Lepage V, Charron D, Schächter F . Mitochondrial genotype associated with French Caucasian centenarians. Gerontology 1998; 44: 349.
Ross OA et al. Mitochondrial DNA polymorphism: its role in longevity of the Irish population. Exp Gerontol 2001; 36: 1161–1178.
Niemi AK et al. Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. Hum Genet 2003; 112: 29–33.
Tanaka M et al. Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis. Mech Ageing Dev 2000; 116: 65–76.
Kokaze A et al. Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population. Hum Genet 2001; 109: 521–525.
Matsunaga H et al. Antiatherogenic mitochondrial genotype in patients with type 2 diabetes. Diabetes Care 2001; 24: 500–503.
Mukae S et al. Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. Circ J 2003; 67: 16–20.
Shimokata H et al. Distribution of genetic disease-related genotypes in the National Institute for Longevity Science, Longitudinal Study of Aging (NILS-LSA). J Epidemiol 2000; 10: S46–S55.
Wang D et al. Association of the mitochondrial DNA 5178 A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients. Exp Clin Endocrinol Diabetes 2001; 109: 361–364.
Ohkubo R et al. Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders. J Neurol Sci 2002; 198: 31–35.
Kornitzer M, Dramaix M, De Backer G . Epidemiology of risk factors for hypertension: implications for prevention and therapy. Drugs 1999; 57: 695–712.
Ueshima H et al. Alcohol drinking and high blood pressure: data from a 1980 national cardiovascular survey of Japan. J Clin Epidemiol 1992; 45: 667–673.
Nakanishi N et al. Risk factors for the development of hypertension: a 6-year longitudinal study of middle-aged Japanese men. J Hypertens 1998; 16: 753–759.
Tsuruta M et al. Association between alcohol intake and development of hypertension in Japanese normotensive men: 12-year follow-up study. Am J Hypertens 2000; 13: 482–487.
Bailey SM, Pietsch EC, Cunningham CC . Ethanol stimulates the production of reactive oxygen species at mitochondrial complex I and III. Free Radio Biol Med 1999; 27: 891–900.
Inoue M et al. Cross-talk between NO and oxyradicals, a supersystem that regulates energy metabolism and survival of animals. Free Radio Res 2000; 33: 757–770.
Iwai N et al. Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension. Circulation 2002; 105: 41–47.
Osanai T et al. Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor. J Clin Invest 2001; 108: 1023–1030.
Atlante A et al. ATP synthesis and export in heart left ventricle mitochondria from spontaneously hypertensive rat. Int J Mol Med 1998; 1: 709–716.
Baba S et al. Blood pressure levels, related factors, and hypertension control status of Japanese and Americans. J Hum Hypertens 1991; 5: 317–332.
Cann RL, Stoneking M, Wilson AC . Mitochondrial DNA and human evolution. Nature 1987; 325: 31–36.
Acknowledgements
This study was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (No. 14570355).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kokaze, A., Ishikawa, M., Matsunaga, N. et al. Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population. J Hum Hypertens 18, 41–45 (2004). https://doi.org/10.1038/sj.jhh.1001632
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.jhh.1001632
Keywords
This article is cited by
-
Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population
BMC Medical Genetics (2019)
-
Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study
BMC Nephrology (2013)
-
Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men
Lipids in Health and Disease (2011)
-
Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men
Journal of Human Genetics (2010)
-
The 5178C/A and 16189T/C polymorphisms of mitochondrial DNA in Korean men and their associations with blood iron metabolism
Molecular Biology Reports (2010)