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Association of the angiotensin-converting enzyme (ACE) gene G2350A dimorphism with essential hypertension

Journal of Human Hypertension volume 17, pages 719–723 (2003)Cite this article

Abstract

Although the angiotensin converting enzyme (ACE) is a strong candidate gene for hypertension, the extensively studied insertion–deletion dimorphism in intron 16 was not found to be associated with it. Several new polymorphisms in the ACE gene were identified, among which a dimorphism in exon 17, ACE G2350A, has a significant effect on plasma ACE concentrations. To assess the value of genotyping the ACE G2350A dimorphism in a genetically homogeneous population, we carried out a retrospective, case–control study of dimorphism G2350A for a putative association with essential hypertension (EH) in a Gulf population (Emirati)–an ethnic group characterized by no alcohol intake and no cigarette smoking. We investigated a sample population of 254 Emirati, comprising 136 normotensive controls, and 118 patients with clinical diagnoses of EH. ACE G2350A alleles were visualized by assays based on polymerase chain reaction and restriction endonuclease analysis. The ACE G2350A dimorphism showed an association with EH (χ2=6.71, 2 df, P=0.05). Further analysis revealed that the ACE G/G 2350 genotype was positively associated (OR=1.06-3.07, P=0.02) with EH. This is the first association study of the ACE G2350A dimorphism with EH, and the positive result might indicate that ACE could be a QTL for EH as originally thought.

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Acknowledgements

We thank Dr Anwar Ali Siddiqui for kindly reviewing the manuscript and providing us with immense support at the Juma Research Lab, which made this work possible.

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Authors and Affiliations

  1. Department of Biological and Biomedical Sciences, Faculty of Health Sciences, The Aga Khan University, Karachi, Pakistan

    M Saeed Mahmood, K Saboohi, S Osman Ali & PM Frossard

  2. Department of Cardiology, Mafraq Hospital, Abu Dhabi, United Arab Emirates

    AM Bokhari

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  1. M Saeed Mahmood
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  2. K Saboohi
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  4. AM Bokhari
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Correspondence to PM Frossard.

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Saeed Mahmood, M., Saboohi, K., Osman Ali, S. et al. Association of the angiotensin-converting enzyme (ACE) gene G2350A dimorphism with essential hypertension. J Hum Hypertens 17, 719–723 (2003). https://doi.org/10.1038/sj.jhh.1001600

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