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Linkage analysis of five candidate genes and essential hypertension in 106 Chinese nuclear families

Journal of Human Hypertension volume 17, pages 69–72 (2003)Cite this article

Abstract

Five candidate genes including the lipoprotein lipase, leptin, leptin receptor, α-adducin and β3 adrenergic receptor were selected to examine their possible contribution to essential hypertension (EH) in a Chinese population. On each side of the candidate gene loci, one to two highly polymorphic microsatellite markers were genotyped in 474 subjects recruited from 106 hypertension nuclear families in Shanghai. Both parametric and nonparametric linkage analyses were carried out using GENEHUNTER (version 2.0) after genotyping. Extended transmission disequilibrium testing (ETDT) was also conducted to detect preferential transmission of alleles to affected offspring. We failed to find the linkage between all these loci and EH by either parametric or nonparametric analysis, nor did we detect any significant transmission disequilibrium by ETDT. Our findings provide no support for a significant contribution of these five genes to the pathogenesis of EH among Shanghai people.

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Acknowledgements

This work was supported by grants of ‘Chinese High Tech Program (863)’ (102-10-02-03 and Z19-01-03-01A) and of the ‘National Key Program on Basic Research’ (G1998051013) from the Ministry of Science and Technology, People's Republic of China. We are deeply indebted to Professor Zhu Chen (Chinese National Human Genome Center at Shanghai) for continuing support and invaluable help.

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Authors and Affiliations

  1. Shanghai Institute of Hypertension, State Key Laboratory for Medical Genomics, Shanghai Second Medical University, Ruijin Hospital, Shanghai, People's Republic of China

    Xin He, Guliang Wang & Zhu Ding-Liang

  2. Chinese National Human Genome Center at Shanghai, Shanghai, People's Republic of China

    Wei Huang

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  1. Xin He
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  2. Guliang Wang
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Correspondence to Zhu Ding-Liang.

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He, X., Wang, G., Huang, W. et al. Linkage analysis of five candidate genes and essential hypertension in 106 Chinese nuclear families. J Hum Hypertens 17, 69–72 (2003). https://doi.org/10.1038/sj.jhh.1001495

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