Abstract
The purpose of the study is to examine the differences in insulin resistance and postprandial triglyceride (TG) response between hypertensive patients with or without hypertriglyceridaemia. The study is a comparative cohort study with matching. Thirty-one newly diagnosed hypertensive patients without any medication were recruited from a health survey. The participants were further divided into two groups: those with fasting TG <2.26 mmol/L, and those with TG between 2.26 and 5.65 mmol/L. Both groups were matched in age, sex, body mass index and waist circumference. Each patient received a 75-g oral glucose tolerance test, an insulin suppression test, and a 1000 kcal high fat mixed meal test. The hypertriglyceridaemic hypertensive patients had significantly higher fasting insulin, 2-h plasma glucose, 2-h insulin, and steady-state plasma glucose (SSPG) (13.16 ± 1.87 vs 9.76 ± 3.18 mmol/L). They also had a greater postprandial TG response to the challenge of mixed meal (ΔAUC 20.76 ± 10.06 vs 7.97 ± 3.18 mmol 8 h/L). The postprandial TG response was closely correlated (r = 0.72–0.95, P < 0.0001) with fasting TG in all hypertensive patients. Both fasting TG levels and postprandial TG response were significantly (P < 0.05) correlated with SSPG. In conclusion, the hypertensive patients with hypertriglyceridaemia were more insulin resistant than those without it. Exacerbation of postprandial hypertriglyceridaemia was identified in these patients. The TG response to the challenge of high fat meal was significantly correlated with fasting TG and insulin resistant in them. The results provide a rationale for the alleviation of insulin resistance and hypertriglyceridaemia in these atherosclerosis-prone hypertensive patients.
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Acknowledgements
The study was supported by the National Health Research Institute ROC (DDH-87-HR-616 and DD-01-86-IX-MG-608S) and Taipei Veterans General Hospital (VAC-86-43 and VAC-89-404-4). Dr Chii-Min Hwu is now a postgraduate scholar supported in part by exchange programs from the Division of Clinical Epidemiology and Preventive Medicine, UCLA and the Choh Hao Li Memorial Fund for Hormone Research, ABMAC.
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Hwu, C., Kwok, C., Kuo, C. et al. Exacerbation of insulin resistance and postprandial triglyceride response in newly diagnosed hypertensive patients with hypertriglyceridaemia. J Hum Hypertens 16, 487–493 (2002). https://doi.org/10.1038/sj.jhh.1001426
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DOI: https://doi.org/10.1038/sj.jhh.1001426
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