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Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans

Journal of Human Hypertension volume 14, pages 385–387 (2000)Cite this article

Abstract

Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of markers located on chromosome 17q to essential hypertension in African Caribbean hypertensive families. No support of linkage was found between the markers studied and hypertension, however only genes of a lamda sib value of less than 1.8 could be excluded

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Authors and Affiliations

  1. Clinical Pharmacology, St Bartholomew’s and The Royal London School of Medicine and Dentistry, London, UK

    J Knight, GTB Gardner & MJ Caulfield

  2. Chemical Endocrinology, St Bartholomew’s and The Royal London School of Medicine and Dentistry, London, UK

    AJL Clark

Authors
  1. J Knight
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  2. GTB Gardner
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  3. AJL Clark
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  4. MJ Caulfield
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Corresponding author

Correspondence to J Knight.

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Cite this article

Knight, J., Gardner, G., Clark, A. et al. Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans. J Hum Hypertens 14, 385–387 (2000). https://doi.org/10.1038/sj.jhh.1001025

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  • DOI: https://doi.org/10.1038/sj.jhh.1001025

Keywords

  • essential hypertension
  • linkage
  • chromosome 17
  • comparative mapping
  • African Caribbean

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