Abstract
Autonomic nervous dysfunction, such as parasympathetic and sympathetic impairment, has been suggested as possible cause of pre-eclampsia, but the studies are not conclusive. Our purpose was to assess non-invasively if pre-eclampsia is associated with a decreased baroreflex function. Nine women with pre-eclampsia (PE), eight normotensive pregnant women, and seven healthy normotensive non-pregnant women were studied. Continuous finger blood pressure was recorded by a Portapres device in the left lateral recumbent position and active standing. Baroreflex gain was evaluated by cross-spectral analysis of systolic blood pressure and pulse interval. The result was that baroreflex gain at rest was lower in pre-eclamptic women both compared to non-pregnant and healthy pregnant subjects (Pā<ā0.05). moreover, a decrease of the baroreflex sensitivity was present in all pregnant women in the orthostatic position (Pā<ā0.05). in conclusion pregnancy per se is associated with a decrease in the baroreflex control of the heart, whereas in pre-eclampsia, the baroreflex sensitivity is impaired further.
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Molino, P., Veglio, F., Genova, G. et al. Baroreflex control of heart rate is impaired in pre-eclampsia. J Hum Hypertens 13, 179ā183 (1999). https://doi.org/10.1038/sj.jhh.1000789
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DOI: https://doi.org/10.1038/sj.jhh.1000789