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High and non-suppressible plasma renin activity in a patient with aldosterone producing adenoma: pathophysiologic and diagnostic implications

Journal of Human Hypertension volume 13, pages 75–78 (1999)Cite this article

Abstract

We describe a case of primary aldosteronism due to an aldosterone producing adenoma with high and non-suppressible plasma renin activity (PRA). She had suppressed PRA at initial diagnosis. This rose above the reference range for normal individuals over a period of 7 years with untreated hypertension. We discuss the possible pathophysiological causes of a rise in PRA in this clinical setting and suggest that underlying arteriolar disease due to prolonged hypertension may be the cause of increased and non-suppressible PRA in primary aldosteronism.

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  1. Department of Endocrinology, Singapore General Hospital, Singapore

    E Shyong Tai & PHK Eng

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  1. E Shyong Tai
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  2. PHK Eng
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Tai, E., Eng, P. High and non-suppressible plasma renin activity in a patient with aldosterone producing adenoma: pathophysiologic and diagnostic implications. J Hum Hypertens 13, 75–78 (1999). https://doi.org/10.1038/sj.jhh.1000727

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  • DOI: https://doi.org/10.1038/sj.jhh.1000727

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