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The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women

International Journal of Obesity volume 32, pages 684–691 (2008)Cite this article

Abstract

Objective:

To determine the effects of a 15-week high-intensity intermittent exercise (HIIE) program on subcutaneous and trunk fat and insulin resistance of young women.

Design and procedures:

Subjects were randomly assigned to one of the three groups: HIIE (n=15), steady-state exercise (SSE; n=15) or control (CONT; n=15). HIIE and SSE groups underwent a 15-week exercise intervention.

Subjects:

Forty-five women with a mean BMI of 23.2±2.0 kg m−2 and age of 20.2±2.0 years.

Results:

Both exercise groups demonstrated a significant improvement (P<0.05) in cardiovascular fitness. However, only the HIIE group had a significant reduction in total body mass (TBM), fat mass (FM), trunk fat and fasting plasma insulin levels. There was significant fat loss (P<0.05) in legs compared to arms in the HIIE group only. Lean compared to overweight women lost less fat after HIIE. Decreases in leptin concentrations were negatively correlated with increases in VO2peak (r=−0.57, P<0.05) and positively correlated with decreases in TBM (r=0.47; P<0.0001). There was no significant change in adiponectin levels after training.

Conclusions:

HIIE three times per week for 15 weeks compared to the same frequency of SSE exercise was associated with significant reductions in total body fat, subcutaneous leg and trunk fat, and insulin resistance in young women.

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References

  1. Speiser PW, Rudolf MCJ, Anhalt H, Comacho-Hubner C, Chiarelli F, Elakim A et al. Consensus statement: childhood obesity. J Clin Endocrinol Metab 2005; 90: 1871–1887.

    Article  CAS  PubMed  Google Scholar 

  2. Jakicic JM, Clark K, Coleman E, Donnelly JE, Foreyt J, Melanson E et al. Appropriate intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 2001; 33: 2145–2156.

    Article  CAS  PubMed  Google Scholar 

  3. Ross R, Dagnone D, Jones PJ, Smith H, Paddags A, Hudson R et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: a randomized, controlled trial. Ann Int Med 2000; 133: 92–103.

    Article  CAS  PubMed  Google Scholar 

  4. Evans EM, Saunders MJ, Spano MA, Arngrimsson A, Lewis RD, Cureton KJ . Effects of diet and exercise on the density and composition of the fat-free mass in obese women. Med Sci Sports Exerc 1999; 31: 1778–1787.

    Article  CAS  PubMed  Google Scholar 

  5. Kraemer WJ, Volek JS, Clark KL, Gordon SE, Puhl SM, Koziris LP et al. Influence of exercise training on physiological and performance changes with weight loss in men. Med Sci Sports Exerc 1999; 31: 1320–1329.

    Article  CAS  PubMed  Google Scholar 

  6. Kyle UG, Gremion G, Genton L, Slosman DO, Golay A, Pichard C . Physical activity and fat-free and fat mass by bioelectrical impedance in 3853 adults. Med Sci Sports Exerc 2001; 33: 576–584.

    Article  CAS  PubMed  Google Scholar 

  7. Shaw K, Gennat H, O’Rourke P, Del Mar C, The Cochrane Collaboration. Exercise for overweight or obesity. Cochrane Database Syst Rev 2006; 4: 1–88.

    Google Scholar 

  8. Burgomaster KA, Hughes SC, Heigenhauser GJF, Bradwell SN, Gibala M . Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans. J Appl Physiol 2005; 98: 1985–1990.

    Article  PubMed  Google Scholar 

  9. Talanian JL, Galloway SDR, Heigenhauser GJF, Bonen A, Spriet LL . Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol 2007; 102: 1439–1447.

    Article  CAS  PubMed  Google Scholar 

  10. Dudley GA, Abraham WM, Terjung RL . Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle. J Appl Physiol 1982; 53: 844–850.

    Article  CAS  PubMed  Google Scholar 

  11. Tremblay A, Simoneau J, Bouchard C . Impact of exercise intensity on body fatness and skeletal muscle metabolism. Metabolism 1994; 43: 814–818.

    Article  CAS  PubMed  Google Scholar 

  12. Thomas S, Reading J, Shephard RJ . Revision of the physical activity readiness questionnaire (PAR-Q). Can J Sport Sci 1992; 17: 338–345.

    CAS  PubMed  Google Scholar 

  13. Schell J, Leelarthaepin B . Physical Fitness Assessment in Exercise and Sport Science 2nd edn. Leelar Biomediscience Services: Matraville, Australia, 1994.

    Google Scholar 

  14. Carey DG, Jenkins AB, Campbell LC, Freund J, Chisholm DJ . Abdominal fat and insulin resistance in normal and overweight women. Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 1996; 45: 633–638.

    Article  CAS  PubMed  Google Scholar 

  15. Bertin E, Marcus C, Ruiz J-C, Eschard J-P, Leutenegger M . Measurement of visceral adipose tissue by DXA combined with anthropometry in obese humans. Int J Obes 2000; 24: 263–270.

    Article  CAS  Google Scholar 

  16. Paradisi G, Smith L, Burtner C, Leaning R, Garvey WT, Hook G et al. Dual energy X-ray absorptiometry assessment of fat mass distribution and its association with the insulin resistance syndrome. Diabetes Care 1999; 22: 1310–1317.

    Article  CAS  PubMed  Google Scholar 

  17. Van MD, Mayclin PL . Body composition assessment: dual-energy X-ray absorptiometry (DEXA) compared to reference methods. Eur J Clin Nutr 1992; 46: 125–130.

    Google Scholar 

  18. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 57–63.

    Article  CAS  PubMed  Google Scholar 

  19. Péronnet F, Massicotte D . Table of nonprotein respiratory quotient: an update. Can J Sport Sci 1991; 16: 23–29.

    PubMed  Google Scholar 

  20. Trapp EG, Chisholm DJ, Boutcher SH . Metabolic response of trained and untrained females during high intensity intermittent cycle exercise. Am J Physiol Regul Integr Comp Physiol 2007 (in press).

  21. Weston M, Helsen W, MacMahon C, Kirkendall D . The impact of specific high-intensity training sessions of football referees’ fitness levels. Am J Sports Med 2004; 32: 54S–61S.

    Article  PubMed  Google Scholar 

  22. Gorostiaga EM, Walter CB, Foster C, Hickson RC . Uniqueness of interval and continuous training at the same maintained exercise intensity. Eur J Appl Physiol Occ Physiol 1991; 63: 101–107.

    Article  CAS  Google Scholar 

  23. Tabata I, Nishimura K, Kouzaki M, Hiral Y, Opgita F, Miyachi M et al. Effects of moderate-intensity endurance and high-intensity intermittent training on anaerobic capacity and VO2max . Med Sci Sports Exerc 1996; 28: 1327–1330.

    Article  CAS  PubMed  Google Scholar 

  24. Bi S, Scott KA, Hyun J, Ladenheim EE, Moran TH . Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima fatty rats: role of hypothamalic signaling. Endocrinology 2007; 146: 1676–1685.

    Article  Google Scholar 

  25. Kawaguchi M, Scott KA, Moran TH, Bi S . Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia. Am J Physiol Regul Integr Comp Physiol 2005; 288: R1800–R1805.

    Article  CAS  PubMed  Google Scholar 

  26. Després JP, Pouliot MC, Moorjani S, Nadeau A, Tremblay A, Lupien PJ et al. Loss of abdominal fat and metabolic response to exercise training in obese women. Am J Physiol 1991; 261: E159–E167.

    PubMed  Google Scholar 

  27. Gaesser GA, Rich RG . Effects of high- and low-intensity exercise training on aerobic capacity and blood lipids. Med Sci Sports Exerc 1984; 16: 269–274.

    CAS  PubMed  Google Scholar 

  28. Grediagin A, Cody M, Rupp J, Bernardot D, Shern R . Exercise intensity does not effect [sic] body composition change in untrained, moderately overfat women. J Am Diet Assoc 1995; 95: 661–665.

    Article  CAS  PubMed  Google Scholar 

  29. Ilmarinen J, Ilmarinen R, Koskela A, Koronen O, Fardy F, Partanen T et al. Training effects of stair-climbing during office hours in female employees. Ergonomics 1979; 22: 507–516.

    Article  CAS  PubMed  Google Scholar 

  30. Jones DM, Squires C, Rodahl K . Effect of rope skipping on physical work capacity. Res Q 1962; 33: 236.

    Google Scholar 

  31. Murphy MH, Hardman AE . Training effects of short and long bouts of brisk walking in sedentary women. Med Sci Sports Exerc 1998; 30: 152–157.

    Article  CAS  PubMed  Google Scholar 

  32. Williford HN, Scharff-Olson M, Blessing DL . Exercise prescription for women. Special considerations. Sports Med 1993; 15: 299–311.

    Article  CAS  PubMed  Google Scholar 

  33. Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjöström L . Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow-up of participants in the population study of women in Gothenberg, Sweden. BMJ 1984; 289: 1261–1263.

    Article  Google Scholar 

  34. Lundgren H, Bengtsson C, Blohme G, Lapidus L . Adiposity and adipose tissue distribution in relation to incidence of diabetes in women: results from a prospective population study in Gothenberg, Sweden. Int J Obes 1989; 13: 413–423.

    CAS  PubMed  Google Scholar 

  35. Saris WHM . The role of exercise in the dietary treatment of obesity. Int J Obes 1993; 17: 17–21.

    Google Scholar 

  36. Gwinup G, Chelvam R, Steinberg T . Thickness of subcutaneous fat and activity of underlying muscles. Ann Intern Med 1971; 74: 408–411.

    Article  CAS  PubMed  Google Scholar 

  37. Katch FI, Clarkson PM, Kroll W, McBride T . Effects of sit up exercise training on adipose cell size and adiposity. Res Q Exerc Sport 1984; 55: 242–247.

    Article  Google Scholar 

  38. Wilmore JH, Atwater AE, Maxwell BD, Wilmore DL, Constable SH, Buono MJ . Alterations in body size and composition consequent to Astro-Trimmer and Slim-Skins training programs. Res Q Exerc Sport 1985; 56: 90–92.

    Article  Google Scholar 

  39. Obisesan TO, Leeuwenburgh C, Ferrell RE, Phares DA, McKenzie JA, Prior SJ et al. C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity. Metab Clin Exp 2006; 55: 453–460.

    Article  CAS  PubMed  Google Scholar 

  40. Ferrannini E, Camastra S, Coppack SW, Fliser D, Golay A, Mitrakou A . Insulin action and non-esterified fatty acids. The European Group for the Study of Insulin Resistance (EGIR). Proc Nutr Soc 1997; 56: 753–761.

    Article  CAS  PubMed  Google Scholar 

  41. Zurlo F, Lillioja S, Esposito-Del Puente A, Nyomba BL, Raz I, Saad MF et al. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 1990; 295: E650–E657.

    Google Scholar 

  42. Markovic TP, Jenkins AB, Campbell LV, Furler SM, Kraegen EW, Chisholm DJ . The determinants of glycemic responses to diet restriction and weight loss in obesity and NIDDM. Diabetes Care 1998; 21: 687–694.

    Article  CAS  PubMed  Google Scholar 

  43. Valera-Mora ME, Simeoni B, Gagliardi L, Scarfone A, Nanni G, Castagneto M et al. Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgery. Am J Clin Nutr 2005; 81: 1292–1297.

    Article  CAS  PubMed  Google Scholar 

  44. Teixeira PJ, Going SB, Houtkooper LB, Cussler EC, Metcalfe LL, Blew RM et al. Pretreatment predictors of attrition and successful weight management in women. Int J Obes Rel Metab Dis 2004; 28: 1124–1133.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia

    E G Trapp, J Freund & S H Boutcher

  2. Garvan Institute, Sydney, New South Wales, Australia

    D J Chisholm

Authors
  1. E G Trapp
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  2. D J Chisholm
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  3. J Freund
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  4. S H Boutcher
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Correspondence to E G Trapp.

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Trapp, E., Chisholm, D., Freund, J. et al. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes 32, 684–691 (2008). https://doi.org/10.1038/sj.ijo.0803781

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  • DOI: https://doi.org/10.1038/sj.ijo.0803781

Keywords

  • intermittent sprinting
  • body fat
  • insulin

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