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Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

International Journal of Obesity volume 32, pages 669–675 (2008)Cite this article

Abstract

Background:

Adiponectin expression and plasma concentrations are decreased in human and animal models of obesity. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene are known to influence the plasmatic concentration of the encoded protein. Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies.

Objective:

The aim of our study was to examine the longitudinal relationships between adiponectin gene polymorphisms and anthropometric indices.

Design:

Two adiponectin gene (ADIPOQ) SNPs, −11391G>A and −11377C>G, were genotyped in 837 French Caucasian subjects from the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort. Anthropometric scores were measured at three clinical examinations over a 7-year period.

Results:

For −11391G>A as well as for −11377C>G, we detected no association between the variant allele and anthropometric measurements at baseline. Considering longitudinal effects, we detected moderately higher waist-to-hip ratio (WHR) changes for the carriers of the −11391A (P=0.02) and −11377C (P=0.03) allele over the follow-up of the study. −11391G>A and −11377C>G define haplotypes associated also with WHR measurements and their changes over the follow-up of the study. Diploid configurations that combine −11391A and −11377C were associated with significantly higher WHR changes (ΔCE: P=0.02) compared to other haplotypes. In addition, higher adiponectin levels were observed in AC/AC diplotypes compared to GG/GG carriers (P<0.0001).

Conclusion:

In the SU.VI.MAX study, genetic variations in the adiponectin gene affect abdominal fat gain over life span.

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Acknowledgements

This work was supported by the Direction de la Recherche Clinique/Assistance Publique-Hôpitaux de Paris, the Programmes Hospitaliers de Recherche Clinique (AOR 02076) and the BQR (bonus qualité recherche of Paris 6 University). We are indebted to Geneviève Bonhonne, Annie Legal and Véronique Pelloux for the constitution of the Danone/SU.VI.MAX DNA Bank and to David Mutch for corrections of the manuscript. The SU.VI.MAX project received support from public and private sectors. Special acknowledgements are addressed to Fruit d'Or Recherche, Lipton, Cereal, Candia, Kellogg's, CERIN, LU/Danone, Sodexho, L'Oréal, Estée Lauder, Peugeot, Jet Service, RP Scherer, France Telecom, Becton Dickinson, Fould Springer, Boehringer Diagnostic, Seppic Givaudan Lavirotte, Le Grand Canal, Air Liquide, Carboxyque, Klocke, Trophy Radio, Jouan, Perkin Elmer.

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Authors and Affiliations

  1. INSERM, U872, Nutriomique (team 7), Cordelier Research Center (CRC), Paris, France

    G Dolley, J-F Bebel, M Guerre-Millo, A Basdevant & K Clément

  2. University Pierre and Marie Curie-Paris 6, Paris, France

    G Dolley, J-F Bebel, M Guerre-Millo, A Basdevant, J-M Oppert, J-M Lacorte & K Clément

  3. Endocrinology and Nutrition Department, Assistance Publique/Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, Paris, France

    G Dolley, A Basdevant, J-M Oppert & K Clément

  4. Center of Research on Human Nutrition Ile de France, CRNH IdF, Paris/Bobigny, France

    G Dolley, S Bertrais, J-F Bebel, M Guerre-Millo, A Basdevant, S Hercberg, P Galan, J-M Oppert & K Clément

  5. INSERM, UMR unit 557; INRA unit 1125; CNAM; University Paris 13,

    S Bertrais, S Hercberg, P Galan & J-M Oppert

  6. INRA unit 1125, Bobigny, France

    S Bertrais, S Hercberg, P Galan & J-M Oppert

  7. Department of Medical Biochemistry, Assistance Publique/Hôpitaux de Paris (AP-HP), UF Nutrigénétique, Pitié-Salpêtrière Hospital, Paris, France

    V Frochot & J-M Lacorte

  8. Integragen, Evry, France

    F Tores, F Rousseau & J Hager

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  1. G Dolley
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Correspondence to K Clément.

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Dolley, G., Bertrais, S., Frochot, V. et al. Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study. Int J Obes 32, 669–675 (2008). https://doi.org/10.1038/sj.ijo.0803773

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  • DOI: https://doi.org/10.1038/sj.ijo.0803773

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