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A randomized trial of the effects of dietary counseling on gestational weight gain and glucose metabolism in obese pregnant women



Can gestational weight gain in obese women be restricted by 10-h dietary consultations and does this restriction impact the pregnancy-induced changes in glucose metabolism?


A randomized controlled trial with or without restriction of gestational weight gain to 6–7 kg by ten 1-h dietary consultations.


Fifty nondiabetic nonsmoking Caucasian obese pregnant women were randomized into intervention group (n=23, 28±4 years, prepregnant body mass index (BMI) 35±4 kg m−2) or control group (n=27, 30±5 years, prepregnant BMI 35±3 kg m−2).


The weight development was measured at inclusion (15 weeks), at 27 weeks, and 36 weeks of gestation. The dietary intakes were reported in the respective weeks by three 7-day weighed food records and blood samples for analyses of fasting s-insulin, s-leptin, b-glucose, and 2-h b-glucose after an oral glucose tolerance test were collected.


The women in the intervention group successfully limited their energy intake, and restricted the gestational weight gain to 6.6 kg vs a gain of 13.3 kg in the control group (P=0.002, 95% confidence interval (CI): 2.6–10.8 kg). Both s-insulin and s-leptin were reduced by 20% in the intervention group compared to the control group at week 27, mean difference: −16 pmol l−1 (P=0.04, 95% CI: −32 to −1) for insulin and −23 ng ml−1 (P=0.004, 95% CI: −39 to −8) for leptin. At 36 weeks of gestation, the s-insulin was further reduced by 23%, −25 pmol l−1 (−47 to −4, P=0.022) and the fasting b-glucose were reduced by 8% compared with the control group (−0.3 mmol l−1, −0.6 to −0.0, P=0.03).


Restriction of gestational weight gain in obese women is achievable and reduces the deterioration in the glucose metabolism.

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Dietitian Anna Marie Kjellingbro, study nurse Hanne Panduro, midwife Margit Holm, MSc Janne Lorentzen, and MSc Camilla Schou Larsen are acknowledged for the skilled and excellent contributions to this study.

Source of funding: Supported by the Desireé and Niels Yde Foundation. Pharma Vinci, Denmark provided vitamins.

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Correspondence to S Wolff.

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Wolff, S., Legarth, J., Vangsgaard, K. et al. A randomized trial of the effects of dietary counseling on gestational weight gain and glucose metabolism in obese pregnant women. Int J Obes 32, 495–501 (2008).

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