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Birth size, adult body composition and muscle strength in later life

Abstract

Objective:

Low birth weight has been linked to lower lean body mass and abdominal obesity later in life, whereas high birth weight has been suggested to predict later obesity as indicated by high body mass index (BMI). We examined how birth weight was related to adult body size, body composition and grip strength.

Design/subjects:

Cross-sectional study on 928 men and 1075 women born in 1934–1944, with measurements at birth recorded.

Measurements:

Height, weight, waist and hip circumference and isometric grip strength were measured. Lean and fat body mass were estimated by bioelectrical impedance with an eight-polar tactile electrode system.

Results:

A 1 kg increase in birth weight corresponded in men to a 4.1 kg (95% CI: 3.1, 5.1) and in women to a 2.9 kg (2.1, 3.6) increase in adult lean mass. This association remained significant after adjustment for age, adult body size, physical activity, smoking status, social class and maternal size. Grip strength was positively related to birth weight through its association with lean mass. The positive association of birth weight with adult BMI was explained by its association with lean mass. Low birth weight was related to higher body fat percentage only after adjustment for adult BMI. Abdominal obesity was not predicted by low birth weight.

Conclusions:

Low birth weight is associated with lower lean mass in adult life and thus contributes to the risk of relative sarcopenia and the related functional inability at the other end of the lifespan. At a given level of adult BMI, low birth weight predicts higher body fat percentage.

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References

  1. Barker DJP . Mothers, babies and health in later life. 2nd edn. Edinburgh: Churchill Livingstone, 1998.

    Google Scholar 

  2. Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991; 303: 1019–1022.

    Article  CAS  Google Scholar 

  3. Leon DA, Lithell HO, Vagero D, Koupilova I, Mohsen R, Berglund L et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15000 Swedish men and women born 1915–1929. BMJ 1998; 317: 241–245.

    Article  CAS  Google Scholar 

  4. Eriksson J, Forsen T, Tuomilehto J, Osmond C, Barker D . Fetal and childhood growth and hypertension in adult life. Hypertension 2000; 36: 790–794.

    Article  CAS  Google Scholar 

  5. Newsome CA, Shiell AW, Fall CH, Phillips DI, Shier R, Law CM . Is birth weight related to later glucose and insulin metabolism? A systematic review. Diabet Med 2003; 20: 339–348.

    Article  CAS  Google Scholar 

  6. Charney E, Goodman HC, McBride M, Lyon B, Pratt R . Childhood antecedents of adult obesity do chubby infants become obese adults? N Engl J Med 1976; 295: 6–9.

    Article  CAS  Google Scholar 

  7. Curhan GC, Chertow GM, Willett WC, Spiegelman D, Colditz GA, Manson JE et al. Birth weight and adult hypertension and obesity in women. Circulation 1996; 94: 1310–1315.

    Article  CAS  Google Scholar 

  8. Rasmussen F, Johansson M . The relation of weight, length and ponderal index at birth to body mass index and overweight among 18-year-old males in Sweden. Eur J Epidemiol 1998; 14: 373–380.

    Article  CAS  Google Scholar 

  9. Eriksson J, Forsen T, Osmond C, Barker D . Obesity from cradle to grave. Int J Obes Relat Metab Disord 2003; 27: 722–727.

    Article  CAS  Google Scholar 

  10. Oken E, Gillman MW . Fetal origins of obesity. Obes Res 2003; 11: 496–506.

    Article  Google Scholar 

  11. Lapillonne A, Braillon P, Claris O, Chatelain PG, Delmas PD, Salle BL . Body composition in appropriate and in small for gestational age infants. Acta Paediatr 1997; 86: 196–200.

    Article  CAS  Google Scholar 

  12. Hediger ML, Overpeck MD, Kuczmarski RJ, McGlynn A, Maurer KR, Davis WW . Muscularity and fatness of infants and young children born small- or large-for-gestational-age. Pediatrics 1998; 102: E60.

    Article  CAS  Google Scholar 

  13. Singhal A, Wells J, Cole TJ, Fewtrell M, Lucas A . Programming of lean body mass: a link between birth weight, obesity, and cardiovascular disease? Am J Clin Nutr 2003; 77: 726–730.

    Article  CAS  Google Scholar 

  14. Gale CR, Martyn CN, Kellingray S, Eastell R, Cooper C . Intrauterine programming of adult body composition. J Clin Endocrinol Metab 2001; 86: 267–272.

    CAS  Google Scholar 

  15. Eriksson J, Forsen T, Tuomilehto J, Osmond C, Barker D . Size at birth, fat-free mass and resting metabolic rate in adult life. Horm Metab Res 2002; 34: 72–76.

    Article  CAS  Google Scholar 

  16. Sayer AA, Syddall HE, Dennison EM, Gilbody HJ, Duggleby SL, Cooper C et al. Birth weight, weight at 1 year of age, and body composition in older men: findings from the Hertfordshire Cohort Study. Am J Clin Nutr 2004; 80: 199–203.

    Article  CAS  Google Scholar 

  17. Kensara OA, Wootton SA, Phillips DI, Patel M, Jackson AA, Elia M . Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen. Am J Clin Nutr 2005; 82: 980–987.

    Article  CAS  Google Scholar 

  18. Law CM, Barker DJ, Osmond C, Fall CH, Simmonds SJ . Early growth and abdominal fatness in adult life. J Epidemiol Community Health 1992; 46: 184–186.

    Article  CAS  Google Scholar 

  19. Byberg L, McKeigue PM, Zethelius B, Lithell HO . Birth weight and the insulin resistance syndrome: association of low birth weight with truncal obesity and raised plasminogen activator inhibitor-1 but not with abdominal obesity or plasma lipid disturbances. Diabetologia 2000; 43: 54–60.

    Article  CAS  Google Scholar 

  20. Garnett SP, Cowell CT, Baur LA, Fay RA, Lee J, Coakley J et al. Abdominal fat and birth size in healthy prepubertal children. Int J Obes Relat Metab Disord 2001; 25: 1667–1673.

    Article  CAS  Google Scholar 

  21. Kuh D, Hardy R, Chaturvedi N, Wadsworth ME . Birth weight, childhood growth and abdominal obesity in adult life. Int J Obes Relat Metab Disord 2002; 26: 40–47.

    Article  CAS  Google Scholar 

  22. Rogers I . The influence of birthweight and intrauterine environment on adiposity and fat distribution in later life. Int J Obes Relat Metab Disord 2003; 27: 755–777.

    Article  Google Scholar 

  23. Reed RL, Pearlmutter L, Yochum K, Meredith KE, Mooradian AD . The relationship between muscle mass and muscle strength in the elderly. J Am Geriatr Soc 1991; 39: 555–561.

    Article  CAS  Google Scholar 

  24. Maltin CA, Delday MI, Sinclair KD, Steven J, Sneddon AA . Impact of manipulations of myogenesis in utero on the performance of adult skeletal muscle. Reproduction 2001; 122: 359–374.

    Article  CAS  Google Scholar 

  25. Kuh D, Bassey J, Hardy R, Aihie Sayer A, Wadsworth M, Cooper C . Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study. Am J Epidemiol 2002; 156: 627–633.

    Article  Google Scholar 

  26. Sayer AA, Syddall HE, Gilbody HJ, Dennison EM, Cooper C . Does sarcopenia originate in early life?. Findings from the Hertfordshire cohort study. J Gerontol A Biol Sci Med Sci 2004; 59: M930–M934.

    Article  Google Scholar 

  27. Rantanen T, Harris T, Leveille SG, Visser M, Foley D, Masaki K et al. Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. J Gerontol A Biol Sci Med Sci 2000; 55: M168–M173.

    Article  CAS  Google Scholar 

  28. Bedogni G, Malavolti M, Severi S, Poli M, Mussi C, Fantuzzi AL et al. Accuracy of an eight-point tactile-electrode impedance method in the assessment of total body water. Eur J Clin Nutr 2002; 56: 1143–1148.

    Article  CAS  Google Scholar 

  29. Malavolti M, Mussi C, Poli M, Fantuzzi AL, Salvioli G, Battistini N et al. Cross-calibration of eight-polar bioelectrical impedance analysis versus dual-energy X-ray absorptiometry for the assessment of total and appendicular body composition in healthy subjects aged 21–82 years. Ann Hum Biol 2003; 30: 380–391.

    Article  CAS  Google Scholar 

  30. Sartorio A, Malavolti M, Agosti F, Marinone PG, Caiti O, Battistini N et al. Body water distribution in severe obesity and its assessment from eight-polar bioelectrical impedance analysis. Eur J Clin Nutr 2005; 59: 155–160.

    Article  CAS  Google Scholar 

  31. Gallagher D, Ruts E, Visser M, Heshka S, Baumgartner RN, Wang J et al. Weight stability masks sarcopenia in elderly men and women. Am J Physiol Endocrinol Metab 2000; 279: E366–E375.

    Article  CAS  Google Scholar 

  32. Syddall H, Cooper C, Martin F, Briggs R, Aihie Sayer A . Is grip strength a useful single marker of frailty? Age Ageing 2003; 32: 650–656.

    Article  Google Scholar 

  33. Broadwin J, Goodman-Gruen D, Slymen D . Ability of fat and fat-free mass percentages to predict functional disability in older men and women. J Am Geriatr Soc 2001; 49: 1641–1645.

    Article  CAS  Google Scholar 

  34. Sternfeld B, Ngo L, Satariano WA, Tager IB . Associations of body composition with physical performance and self-reported functional limitation in elderly men and women. Am J Epidemiol 2002; 156: 110–121.

    Article  Google Scholar 

  35. Heitmann BL, Erikson H, Ellsinger BM, Mikkelsen KL, Larsson B . Mortality associated with body fat, fat-free mass and body mass index among 60-year-old swedish men-a 22-year follow-up. The study of men born in 1913. Int J Obes Relat Metab Disord 2000; 24: 33–37.

    Article  CAS  Google Scholar 

  36. Pouliot MC, Despres JP, Lemieux S, Moorjani S, Bouchard C, Tremblay A et al. Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol 1994; 73: 460–468.

    Article  CAS  Google Scholar 

  37. WHO Reports. World Health Organization: Geneva, Switzerland, 2003.

  38. Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJ . Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ 1999; 318: 427–431.

    Article  CAS  Google Scholar 

  39. Law CM, Shiell AW, Newsome CA, Syddall HE, Shinebourne EA, Fayers PM et al. Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age. Circulation 2002; 105: 1088–1092.

    Article  CAS  Google Scholar 

  40. Lawlor DA, Davey Smith G, Ebrahim S . Life course influences on insulin resistance: findings from the British Women's Heart and Health Study. Diabetes Care 2003; 26: 97–103.

    Article  Google Scholar 

  41. Barker DJ, Osmond C, Forsen TJ, Kajantie E, Eriksson JG . Trajectories of growth among children who have coronary events as adults. N Engl J Med 2005; 353: 1802–1809.

    Article  CAS  Google Scholar 

  42. Eriksson JG, Yliharsila H, Forsen T, Osmond C, Barker DJ . Exercise protects against glucose intolerance in individuals with a small body size at birth. Prev Med 2004; 39: 164–167.

    Article  CAS  Google Scholar 

  43. Harman D . Aging: overview. Ann NY Acad Sci 2001; 928: 1–21.

    Article  CAS  Google Scholar 

  44. Strawbridge WJ, Cohen RD, Shema SJ, Kaplan GA . Successful aging: predictors and associated activities. Am J Epidemiol 1996; 144: 135–141.

    Article  CAS  Google Scholar 

  45. Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998; 147: 755–763.

    Article  CAS  Google Scholar 

  46. Visser M, Langlois J, Guralnik JM, Cauley JA, Kronmal RA, Robbins J et al. High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study. Am J Clin Nutr 1998; 68: 584–590.

    Article  CAS  Google Scholar 

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Acknowledgements

The study has been supported by Academy of Finland, British Heart Foundation, Finnish Diabetes Research Foundation, Finnish Foundation for Cardiovascular Research, Finnish Medical Society Duodecim, Finska Läkaresällskapet, Jalmari and Rauha Ahokas Foundation, Juho Vainio Foundation, Päivikki and Sakari Sohlberg Foundation, Signe and Ane Gyllenberg Foundation, and Yrjö Jahnsson Foundation.

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Correspondence to H Ylihärsilä.

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Ylihärsilä, H., Kajantie, E., Osmond, C. et al. Birth size, adult body composition and muscle strength in later life. Int J Obes 31, 1392–1399 (2007). https://doi.org/10.1038/sj.ijo.0803612

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  • DOI: https://doi.org/10.1038/sj.ijo.0803612

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