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Long-term effects of consumption of a novel fat emulsion in relation to body-weight management



To assess weight maintenance after weight loss by consumption of yoghurt with a novel fat emulsion (Olibra) including effects on body composition, resting energy expenditure (REE), fat oxidation, hunger feelings and satiety hormones.


A randomized, placebo-controlled, double-blind, parallel design. A 6-week weight loss period (2.1 MJ/day) was followed by 18 weeks weight maintenance with test (Olibra) or placebo yoghurt.


Fifty overweight women (age: 18–58 years, body mass index (BMI) 25–32 kg/m2).


In weeks 1, 7 and 25, a satiety test with questionnaires and blood samples for analysis of satiety hormones. In weeks 2, 8 and 26, REE, body weight and body composition.


During weight maintenance after significant body weight reduction, there was no significant increase in body weight in the test group (1.1±3.4 kg); the placebo group did gain weight (3.0±3.1 kg, P<0.001). Compared to the placebo group, the test group was less hungry 4 h after yoghurt consumption in week 25 (P<0.05) and showed increased glucagon like peptide-1 values 180 min after yoghurt consumption (week 25 vs week 1, P<0.05). Measured REE as a function of fat-free mass (FFM) was significantly higher than predicted REE (P<0.05) in week 26 for the test group, but not for the placebo group. Fat mass (FM) was significantly more decreased in the test group (6.5±4.1 kg) compared to the placebo group (4.1±3.6 kg) (week 26 vs week 2, P<0.05).


Consumption of Olibra yoghurt improved weight maintenance compared to placebo, which can be explained by the relatively higher REE as a function of FFM, relatively higher decrease in FM and the relatively lower increase in hunger.

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We gratefully acknowledge Roy Langeveld, Manuela Lejeune, Natalie Luscombe-Marsh, Joan Senden, Wendy Sluijsmans, Astrid Smeets, Jos Stegen, Loek Wouters and Peter Zuurendonk. The study was funded by Campina Innovation, Wageningen, The Netherlands. The Olibra fat emulsion was provided by Lipid Technologies Provider AB, Karlshamn, Sweden.

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Correspondence to K Diepvens.

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The study was sponsored by Campina Innovation, Wageningen, The Netherlands, which raises potential duality of interest.

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Diepvens, K., Soenen, S., Steijns, J. et al. Long-term effects of consumption of a novel fat emulsion in relation to body-weight management. Int J Obes 31, 942–949 (2007).

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