Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Sugars-containing beverages and post-prandial satiety and food intake

Abstract

Reports from food disappearance and food intake surveys, and from prospective and intervention studies appear to support a contributing role for sugars-sweetened beverages in obesity. Often these studies are interpreted to imply that there is a direct causal link between sugars consumption, especially from beverages, and obesity. The purpose of this review is to determine if the associations reported between sugars consumption and obesity are biologically plausible. The evaluation of biologic plausibility is examined by answering the following five questions: (1) Do sugars and sugars in solutions bypass food intake regulatory systems? (2) Do sugars and sugars in solutions suppress food intake? (3) Do sugars sweetened, commercially available beverages (e.g. soft drinks) suppress food intake? (4) Do sugars in solid form stimulate intake regulatory systems and suppress food intake more than those in beverages? and (5) Do energy-containing beverages contribute to energy imbalances because regulatory systems for hunger and thirst interact? It is concluded that the associations between sugars-sweetened beverages and obesity must be viewed as circumstantial because biological plausibility, based on known physiologic mechanisms regulating food intake and energy balance, and short-term experimental studies, does not support cause and effect conclusions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Elliott S, Keim NL, Stern JS, Teff K, Havel PJ . Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002; 76: 911–922.

    Article  CAS  Google Scholar 

  2. Anderson GH, Woodend D . Consumption of sugar and the regulation of short-term satiety and food intake. Am J Clin Nutr 2003; 78: 843–849.

    Article  Google Scholar 

  3. Bray GA, Nielsen SJ, Popkin BM . Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004; 79: 537–543.

    Article  CAS  Google Scholar 

  4. Harnack L, Stang J, Story M . Soft drink consumption among US children and adolescents: nutritional consequences. J Am Diet Assoc 1999; 99: 436–441.

    Article  CAS  Google Scholar 

  5. Pereira MA . The possible role of sugar-sweetened beverages in obesity etiology: a reveiw of the evidence. I Int J Obes 2006; 30: S28–S36.

    Article  Google Scholar 

  6. Pancoast HM, Junk WR . Handbook of Sugars 2nd edn, AVI Pub Co.: Westport CT, 1980. pp 81–112.

    Google Scholar 

  7. Anderson GH, Stewart S, Kaplan R . Carbohydrate behavior, and health. Brain Med Bull 1998; 20: 69–76.

    Google Scholar 

  8. Southgate D, Paul AA, Dean AC, Christie AA . Free sugars in foods. J Hum Nutr 1978; 32: 335–347.

    CAS  PubMed  Google Scholar 

  9. Park YK, Yetley EA . Intakes and food sources of fructose in the United States. Am J Clin Nutr 1993; 58 (Suppl 5): 737–747.

    Article  Google Scholar 

  10. Hanover LM, White JS . Manufacturing, composition, and applications of fructose. Am J Clin Nutr 1993; 58 (Suppl 5): 724–732.

    Article  Google Scholar 

  11. USDA. US per Capita Food Consumption. United States Department of Agriculture, Economic Reseach Services: Beltsville, MD, 2006.

  12. Harnack LJ, Jeffery RW, Boutelle KN . Temporal trends in energy intake in the United States an ecologic perspective. Am J Clin Nutr 2000; 71: 1478–1484.

    Article  CAS  Google Scholar 

  13. Vuilleumier S . Worldwide production of high-fructose syrup and crystalline fructose. Am J Clin Nutr 1993; 58: 733–736.

    Article  Google Scholar 

  14. Ludwig DS, Peterson KE, Gortmaker SL . Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 2001; 357: 505–508.

    Article  CAS  Google Scholar 

  15. Canty DJ, Chan MM . Effects of consumption of energy-containing vs non-energy-containing sweet drinks on indices of hunger and food consumption in normal adults. Am J Clin Nutr 1991; 53: 1159–1164.

    Article  CAS  Google Scholar 

  16. Wylie-Rosett J, Segal-Isaacson CJ, Segal-Isaacson A . Carbohydrates and increases in obesity: does the type of carbohydrate make a difference? Obes Res 2004; 12 (Suppl 2): 124–129.

    Article  Google Scholar 

  17. Anderson GH . Regulation of food intake. In: ME Shils, Olson JA, Shike M (eds). Modern Nutrition in Health and Disease. Lea and Febiger: Phyladelphia, PA, USA, 1994. pp 524–536.

    Google Scholar 

  18. Mayer J . Glucostatic mechanism of the regulation of food intake. N Engl J Med 1953; 249: 13–16.

    Article  CAS  Google Scholar 

  19. Campfield LA, Smith FJ, Rosenbaum M, Hirsch J . Human eating: evidence for a physiological basis using a modified paradigm. Neurosci Biobehav Rev 1996; 20: 133–137.

    Article  CAS  Google Scholar 

  20. Campfield LA, Smith FJ . Blood glucose dynamics and control of meal initiation: a pattern detection and recognition theory. Physiol Rev 2003; 83: 25–58.

    Article  CAS  Google Scholar 

  21. Chapman IM, Goble EA, Wittert GA, Morley JE, Horowitz M . Effect of intravenous glucose and euglycemic insulin infusions on short term appetite and food intake. Am J Physiol 1998; 274 (Part 2): R596–R603.

    CAS  PubMed  Google Scholar 

  22. Gielkens HA, Verkijk M, Lam WF, Lamers CB, Masclee AA . Effects of hyperglycemia and hyperinsulinemia on satiety in humans. Metabolism 1998; 47: 321–324.

    Article  CAS  Google Scholar 

  23. Anderson GH, Catherine NL, Woodend DM, Wolever TM . Inverse association between the effect of carbohydrates on blood glucose and subsequent short-term food intake in young men. Am J Clin Nutr 2002; 76: 1023–1030.

    Article  CAS  Google Scholar 

  24. Melanson KJ, Westerterp-Plantenga MS, Campfield LA, Saris WHM . Blood glucose and meal patterns in time-blinded males, after aspartame, carbohydrate, and fat consumption, in relation to sweetness perception. Br J Nutr 1999; 82: 437–446.

    CAS  PubMed  Google Scholar 

  25. Reid M, Hammersley R . The effects of sucrose and maize oil on subsequent food intake and mood. Br J Nutr 1999; 82: 447–455.

    CAS  PubMed  Google Scholar 

  26. Woodend DM, Anderson GH . Effect of sucrose and safflower oil preloads on short term appetite and food intake of young men. Appetite 2001; 26: 384–388.

    Google Scholar 

  27. Anderson GH . Hunger, appetite, and food intake. In: Ziegler EE, Filer LJ (eds). Present Knowledge in Nutrition 7th edn ILSI Press: Washington, DC, 1996. pp 13–17.

    Google Scholar 

  28. Woods SC . Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake. Am J Physiol Gastrointest Liver Physiol 2004; 286: G7–G13. review.

    Article  CAS  Google Scholar 

  29. Woods SC, Figlewicz Lattemann DP, Schwartz MW, Porte Jr D . A re-assessment of the regulation of adiposity and appetite by the brain insulin system. Int J Obes 1990; 14 (Suppl 3): 69–73; discussion 74–76.

    PubMed  Google Scholar 

  30. Holt SH, Brand Miller JC, Petocz P . Interrelationships among postprandial satiety, glucose and insulin responses and changes in subsequent food intake. Eur J Clin Nutr 1996; 50: 788–797.

    CAS  PubMed  Google Scholar 

  31. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG . Central nervous system control of food intake. Nature 2000; 404: 661–671.

    Article  CAS  Google Scholar 

  32. Woods SC, Seeley RJ, Porte Jr D, Schwartz MW . Signals that regulate food intake and energy homeostasis. Science 1998; 280: 1378–1383.

    Article  CAS  Google Scholar 

  33. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte Jr D . Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev 1992; 13: 387–414.

    CAS  PubMed  Google Scholar 

  34. Koopmans HS, Walls EK, Willing AE . Does the integrated level of all plasma nutrients control daily food intake? Brain Res Bull 1991; 27: 429–434.

    Article  CAS  Google Scholar 

  35. de Graaf C, Blom WA, Smeets PA, Stafleu A, Hendriks HF . Biomarkers of satiation and satiety. Am J Clin Nutr 2004; 79: 946–961.

    Article  CAS  Google Scholar 

  36. Lavin JH, Read NW . The effect on hunger and satiety of slowing the absorption of glucose: relationship with gastric emptying and postprandial blood glucose and insulin responses. Appetite 1995; 25: 89–96.

    Article  CAS  Google Scholar 

  37. Bray GA . Afferent signals regulating food intake. Proc Nutr Soc 2000; 59: 373–384.

    Article  CAS  Google Scholar 

  38. Stewart SL, Black R, Wolever TMS, Anderson GH . The relationship between the glycaemic response to breakfast cereals and subjective appetite and food intake. Nutr Res 1997; 17: 1249–1260.

    Article  CAS  Google Scholar 

  39. Tappy L, Jequier E . Fructose and dietary thermogenesis. Am J Clin Nutr 1993; 58 (Suppl 5): 766–770.

    Article  Google Scholar 

  40. Birch LL, Mcphee L, Sullivan S . Children's food intake following drinks sweetened with sucrose or aspartame, time course effects. Physiol Behav 1989; 45: 387–395.

    Article  CAS  Google Scholar 

  41. Birch LL, Fisher JO . Food intake regulation in children. Fat and sugar substitutes and intake. Ann NY Acad Sci 1997; 819: 194–220.

    Article  CAS  Google Scholar 

  42. Anderson GH, Woodend D . Effect of glycemic carbohydrates on short-term satiety and food intake. Nutr Rev 2003; 61 (Part 2): 17–26.

    Article  Google Scholar 

  43. Blundell JE, Macdiarmid JI . Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating. J Am Diet Assoc 1997; 97: 63–69.

    Article  Google Scholar 

  44. Blundell JE, Green S, Burley V . Carbohydrates and human appetite. Am J Clin Nutr 1994; 59: 728–734.

    Article  Google Scholar 

  45. Lavin JH, French SJ, Ruxton CH, Read NW . An investigation of the role of oro-sensory stimulation in sugar satiety? Int J Obes Relat Metab Disord 2002; 26: 384–388.

    Article  CAS  Google Scholar 

  46. Anderson GH . Sugars, sweetness and food intake. Am J Clin Nutr 1995; 62: 195–202.

    Article  Google Scholar 

  47. Lavin JH, French SJ, Read NW . Comparison of oral and gastric administration of sucrose and maltose on gastric emptying rate and appetite. Int J Obes Relat Metab Disord 2002; 26: 80–86.

    Article  CAS  Google Scholar 

  48. Anderson GH, Saravis S, Schacher R, Zlotkin S, Leiter L . Aspartame: effect on lunch-time food intake, appetite and hedonic response in children. Appetite 1989; 13: 93–103.

    Article  CAS  Google Scholar 

  49. Rolls BJ, Kim S, Fedoroff IC . Effects of drinks sweetened with sucrose or aspartame on hunger, thirst and food intake in men. Physiol Behav 1990; 48: 19–26.

    Article  CAS  Google Scholar 

  50. Rolls BJ, Hetherington M, Laster LJ . Comparison of the effects of aspartame and sucrose on food intake. Appetite 1988; 11 (Suppl): 62–67.

    Article  CAS  Google Scholar 

  51. Rogers PJ, Carlyle JA, Hill AJ, Blundell JE . Uncoupling sweet taste and calories: comparison of the effects of glucose and three intense sweeteners on hunger and food intake. Physiol Behav 1988; 43: 547–552.

    Article  CAS  Google Scholar 

  52. Rogers PJ, Blundell JE . Separating the actions of sweetness and calories: effects of saccharin and carbohydrates on hunger and food intake in human subjects. Physiol Behav 1989; 45: 1093–1099.

    Article  CAS  Google Scholar 

  53. Walter SJ . Effect of low and high GI carbohydrate on blood glucose and food intake at two or four hours in young men MSc thesis, University of Toronto, pp 1–112.

  54. Spitzer L, Rodin J . Effects of fructose and glucose preloads on subsequent food intake. Appetite 1987; 8: 135–145.

    Article  CAS  Google Scholar 

  55. Rodin J . Comparative effects of fructose, aspartame, glucose and water preloads on calorie and macronutrient intake. Am J Clin Nutr 1990; 51: 428–435.

    Article  CAS  Google Scholar 

  56. Rodin J, Reed D, Jamner L . Metabolic effect of fructose and glucose: implications for food intake. Am J Clin Nutr 1988; 47: 683–689.

    Article  CAS  Google Scholar 

  57. Rodin J . Effects of pure sugar vs mixed starch fructose loads on food intake. Appetite 1991; 17: 213–219.

    Article  CAS  Google Scholar 

  58. Ravich WJ, Bayless TM, Thomas M . Fructose: incomplete intestinal absorption in humans. Gastroenterology 1983; 84: 26–29.

    CAS  PubMed  Google Scholar 

  59. Riby JE, Fujisawa T, Kretchmer N . Fructose absorption. Am J Clin Nutr 1993; 58 (Suppl): 748–753.

    Article  Google Scholar 

  60. Crapo PA, Kolterman OG, Olefsky JM . Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects. Diabetes Care 1980; 3: 575–582.

    Article  CAS  Google Scholar 

  61. Horowitz M, Cunningham KM, Wishart JM, Jones KL, Read NW . The effect of short-term dietary supplementation with glucose on gastric emptying of glucose and fructose and oral glucose tolerance in normal subjects. Diabetologia 1996; 39: 481–486.

    Article  CAS  Google Scholar 

  62. Lee BM, Wolever TMS . Effect of glucose, sucrose and fructose on plasma glucose and insulin responses in normal humans: comparison with white bread. Eur J Clin Nutr 1998; 52: 924–928.

    Article  CAS  Google Scholar 

  63. Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 2004; 89: 2963–2972.

    Article  CAS  Google Scholar 

  64. Bantle JP, Raatz SK, Thomas W, Georgopoulos A . Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 2000; 72: 1128–1134.

    Article  CAS  Google Scholar 

  65. Gibney M, Sigman-Grant M, Stanton Jr JL, Keast DR . Consumption of sugars. Am J Clin Nutr 1995; 62 (Suppl 1): 178–193.

    Article  Google Scholar 

  66. Akgun S, Ertel NH . The effects of sucrose, fructose, and high-fructose corn syrup meals on plasma glucose and insulin in non-insulin-dependent diabetic subjects. Diabetes Care 1985; 8: 279–283.

    Article  CAS  Google Scholar 

  67. Dietz WH . Sugar-sweetened beverages, milk intake, and obesity in children and adolescents. J Pediatr 2006; 148: 152–154.

    Article  Google Scholar 

  68. Striegel-Moore RH, Thompson D, Affenito SG, Franko DL, Obarzanek E, Barton BA et al. Correlates of beverage intake in adolescent girls: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 2006; 148: 183–187.

    Article  Google Scholar 

  69. Almiron-Roig E, Drewnowski A . Hunger, thirst, and energy intakes following consumption of energy-containing beverages. Physiol Behav 2003; 79: 767–773.

    Article  CAS  Google Scholar 

  70. Almiron-Roig E, Flores SY, Drewnowski A . No difference in satiety or in subsequent energy intakes between a beverage and a solid food. Physiol Behav 2004; 82: 671–677.

    Article  CAS  Google Scholar 

  71. DellaValle DM, Roe LS, Rolls BJ . Does the consumption of energy-containing and non-energy-containing beverages with a meal affect energy intake? Appetite 2005; 44: 187–193.

    Article  Google Scholar 

  72. Mattes R . Beverages and positive energy balances: the menace is not the medium. I Int J Obes 2006; 30: S60–S65.

    Article  Google Scholar 

  73. Mattes RD . Dietary compensation by humans for supplemental energy provided as ethanol or carbohydrate in fluids. Physiol Behav 1996; 59: 179–187.

    Article  CAS  Google Scholar 

  74. Mattes R . Fluid calories and energy balance: The good, the bad, and the uncertain. Physiol Behav 2006; 3: 3.

    Google Scholar 

  75. DiMeglio DP, Mattes RD . Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes Relat Metab Disord 2000; 24: 794–800.

    Article  CAS  Google Scholar 

  76. Almiron-Roig E, Chen Y, Drewnowski A . Liquid calories and the failure of satiety: how good is the evidence? Obes Rev 2003; 4: 201–212.

    Article  CAS  Google Scholar 

  77. Ritz P, Berrut G . The importance of good hydration for day-to-day health. Nutr Rev 2005; 63: 6–13.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to G H Anderson.

Additional information

Presented at the Workshop ‘Simple Carbohydrates and Obesity, 5–6 April Utrecht.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Anderson, G. Sugars-containing beverages and post-prandial satiety and food intake. Int J Obes 30 (Suppl 3), S52–S59 (2006). https://doi.org/10.1038/sj.ijo.0803493

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ijo.0803493

Keywords

This article is cited by

Search

Quick links