Change in clinical and biochemical measurements with the intervention. Data analysed using random effects models of the change in outcome variable, adjusted for baseline values. Where significant time*group effects exist, between group significances are shown on figures. Significant differences, * WLFO vs Control, †WLPO vs Control and ‡WLFO vs WLPO. Significance indicated by increasing number of symbols (P<0.05, P<0.01 and P<0.0001, respectively). Within group significances, not shown in figure, are described fully in the text.