Table 1 Plasma variables in dietary obese rats following 15 days of administration of vehicle or NNC 38-1049

From: Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight

  Treatments
Plasma Vehicle NNC 38-1049 (mg/kg) a
variables Full nutrition Restricted b 2 × 10 c 2 × 20 c
Metabolites (mmol/L)     
BHBTd 0.21±0.03 0.20±0.02 0.21±0.02 0.42±0.13
TGe 3.16±0.43 2.99±0.42 2.35±0.27 *1.69±0.27
FFA 0.14±0.02 0.11±0.02 0.18±0.04 0.17±0.03
Glucose 6.84±0.13 6.57±0.15 6.87±0.12 6.8±0.21
Hormones     
Insulin (pmol/l) 377±62.0 437±97.4 445±88.2 351±64.6
Leptin (μg/l) 19.0±2.48 14.8±2.19 19.5±3.73 16.27±2.73
  1. *Significantly (P<0.05) different from vehicle controls on full nutrition after ANOVA, followed by Dunnett's test for multiple comparisons.
  2. aNNC 38-1049: histamine H3 receptor antagonist NNC 0038-000-1049.
  3. bFood restricted: food intake was restricted to 75% of full nutrition.
  4. c2 × 10: one dose of 10 mg/kg was given at the beginning of the feeding period and another dose of 10 mg/kg 3.5 h later.
  5. dBHBT: β-hydroxybutyrate.
  6. eTG: triglycerides.
  7. Data represent means (n=14–15)±s.e.m.