Table 3 Mortality rates and hazard ratios for selected site–specific cancer deaths in relation to obesity and overweight

From: Obesity and overweight in relation to organ-specific cancer mortality in London (UK): findings from the original Whitehall study

Type of cancer (total no. of deaths) Normal (18.5–24.9kg/m2) Overweight (25.0–29.9kg/m2) Obese (≥30 kg/m2) P for trend
Number of subjects 9288 7097 717
All cancers (3051)
 Mortality ratea (no. of deaths) 7.66 (1648) 7.53 (1279) 7.88 (124)
 Age adjustedb 1.0 (ref) 1.00 (0.93,1.07) 1.14 (0.95,1.37) 0.69
 Multiply adjustedc 1.0 1.05 (0.97,1.13) 1.21 (1.00,1.48) 0.08
 Multiply adjusted—excluding first 10 yd 1.0 1.04 (0.95,1.13) 1.17 (0.94,1.45) 0.20
 Multiply adjusted—excluding first 20 ye 1.0 1.09 (0.98,1.22) 1.09 (0.81,1.47) 0.13
Lung (783)
 Mortality rate (no. of deaths) 2.20 (450) 1.85 (308) 1.55 (25)  
 Age adjusted 1.0 0.85 (0.73, 0.98) 0.77 (0.51, 1.15) 0.007
 Multiply adjusted 1.0 0.99 (0.85, 1.16) 1.00 (0.65, 1.53) 0.98
 Multiply adjusted—excluding first 10 y 1.0 0.96 (0.80, 1.15) 1.15 (0.72, 1.83) 0.98
 Multiply adjusted—excluding first 20 y 1.0 1.01 (0.79, 1.30) 1.07 (0.53, 2.16) 0.85
Prostate (431)     
 Mortality rate (no. of deaths) 1.14 (243) 1.02 (175) 0.81 (13)  
 Age adjusted 1.0 0.93 (0.76, 1.12) 0.88 (0.50, 1.54) 0.42
 Multiply adjusted 1.0 0.92 (0.75, 1.13) 0.91 (0.51, 1.63) 0.45
 Multiply adjusted—excluding first 10 y 1.0 0.91 (0.74, 1.13) 0.80 (0.43, 1.51) 0.33
 Multiply adjusted—excluding first 20 y 1.0 0.95 (0.74, 1.22) 0.76 (0.35, 1.67) 0.54
Colon (279)
 Mortality rate (no. of deaths) 0.64 (139) 0.72 (122) 1.18 (18)  
 Age adjusted 1.0 1.14 (0.89, 1.46) 2.00 (1.22, 3.26) 0.03
 Multiply adjusted 1.0 1.20 (0.93, 1.56) 2.21 (1.29, 3.79) 0.02
 Multiply adjusted—excluding first 10 y 1.0 1.20 (0.90, 1.60) 2.14 (1.15, 3.99) 0.05
 Multiply adjusted—excluding first 20 y 1.0 1.42 (1.01, 2.01) 1.37 (0.53, 3.56) 0.07
Stomach (190)
 Mortality rate (no. of deaths) 0.48 (100) 0.49 (81) 0.56 (9)  
 Age adjusted 1.0 1.02 (0.76, 1.37) 1.27 (0.64, 2.52) 0.70
 Multiply adjusted 1.0 1.05 (0.76, 1.44) 1.23 (0.59, 2.58) 0.60
 Multiply adjusted—excluding first 10 y 1.0 1.13 (0.78, 1.62) 1.80 (0.81, 3.99) 0.22
 Multiply adjusted—excluding first 20 y 1.0 0.92 (0.55, 1.51) 1.30 (0.38, 4.51) 0.95
Lymphoma (158)
 Mortality rate (no. of deaths) 0.33 (77) 0.42 (74) 0.44 (7)  
 Age adjusted 1.0 1.30 (0.94, 1.79) 1.46 (0.67, 3.16) 0.08
 Multiply adjusted 1.0 1.34 (0.95, 1.89) 1.49 (0.65, 3.42) 0.10
 Multiply adjusted—excluding first 10 y 1.0 1.25 (0.86, 1.81) 1.61 (0.69, 3.74) 0.18
 Multiply adjusted—excluding first 20 y 1.0 1.33 (0.84, 2.09) 1.92 (0.70, 5.25) 0.15
Pancreas (147)
 Mortality rate (no. of deaths) 0.36 (75) 0.41 (69) 0.20 (3)  
 Age adjusted 1.0 1.19 (0.86, 1.66) 0.61 (0.19, 1.93) 0.77
 Multiply adjusted 1.0 1.18 (0.83, 1.68) 0.58 (0.18, 1.91) 0.80
 Multiply adjusted—excluding first 10 y 1.0 1.13 (0.77, 1.66) 0.43 (0.10, 1.84) 0.90
 Multiply adjusted—excluding first 20 y 1.0 1.24 (0.76, 2.03) 0.86 (0.19, 3.76) 0.57
  1. aAge-adjusted mortality rates per 1000 person-years;
  2. bResults are hazards ratio (95% CI).
  3. cMultiply adjusted model—adjusted for age, plus employment grade, physical activity, smoking habit, marital status, disease at entry, weight loss in the last year, blood pressure-lowering medication, height adjusted FEV1, triceps skinfold thickness, systolic blood pressure, plasma cholesterol, glucose intolerance and diabetes status.
  4. dDeaths in the first 10 y of surveillance are excluded.
  5. eDeaths in the first 20 y of surveillance are excluded.