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Serum adiponectin concentrations during a 72-hour fast in over- and normal-weight humans

International Journal of Obesity volume 29, pages 998–1001 (2005)Cite this article

Abstract

OBJECTIVE:

Adiponectin is currently considered an important link between obesity and insulin resistance, since circulating levels of this insulin sensitizing hormone have consistently been found to be reduced in obese subjects. However, until now it is not known how the secretion of adiponectin is regulated in response to acute metabolic changes. Here, we assessed the influence of complete fasting for 72 h on serum adiponectin levels.

DESIGN:

Between group comparison of repeated measurements.

SUBJECTS:

In total, 18 normal-weight (mean±s.e.m. BMI: 22.2±0.4 kg/m2; age: 39.2±4.4 y) and nine over-weight (BMI: 33.2±1.8 kg/m2; age: 36.9±4.5 y) subjects.

MEASUREMENTS:

Serum adiponectin levels were measured every 4 h during a 72-h fasting period. Additionally, concentrations of plasma glucose and serum insulin and leptin were assessed at the beginning and in the end of the fasting experiment. Insulin resistance was estimated using the homeostasis model assessment (HOMA).

RESULTS:

While concentrations of glucose, insulin, and leptin decreased across the fasting period by 31.0, 33.1 and 60.0%, respectively (all P<0.005), adiponectin levels remained unchanged (P=0.817). Overall, over-weight subjects exhibited slightly lower adiponectin levels than normal-weight subjects (P=0.092), but there was no difference in the time course of adiponectin levels during fasting between these two groups (P=0.970). Although, averaged adiponectin levels before and after fasting did not systematically differ, individual changes in adiponectin levels across fasting displayed a slight but significant inverse correlation with changes in plasma glucose concentration (r=−0.42, P=0.03).

DISCUSSION:

The data show that serum adiponectin concentrations remain remarkably stable during 72 h of fasting in normal- and over-weight subjects. Thus, adiponectin appears to reflect primarily long-term changes in body weight with little evidence for a dependence on short-term regulatory influences.

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References

  1. Chandran M, Phillips SA, Ciaraldi T, Henry RR . Adiponectin: more than just another fat cell hormone? Diabetes Care 2003; 26: 2442–2450.

    Article  CAS  Google Scholar 

  2. Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, Orlova C, Mantzoros CS . Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 2003; 88: 4823–4831.

    Article  CAS  Google Scholar 

  3. Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF . Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003; 361: 226–228.

    Article  CAS  Google Scholar 

  4. Kraemer RR, Aboudehen KS, Carruth AK, Durand RT, Accvcdo EO, Hebert EP, Johnson LG, Castracanc VD . Adiponectin responses to continuous and progressively intense intermittent exercise. Med Sci Sports Exerc 2003; 35: 1320–1325.

    Article  CAS  Google Scholar 

  5. Esposito K, Nappo F, Giugliano F, Di Palo C, Ciotola M, Barbieri M, Paolisso G, Giugliano D . Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus. Am J Clin Nutr 2003; 78: 1135–1140.

    Article  CAS  Google Scholar 

  6. Peake PW, Kriketos AD, Denyer GS, Campbell LV, Charlesworth JA . The postprandial response of adiponectin to a high-fat meal in normal and insulin-resistant subjects. Int J Obes Relat Metab Disord 2003; 27: 657–662.

    Article  CAS  Google Scholar 

  7. English PJ, Coughlin SR, Hayden K, Malik IA, Wilding JP . Plasma adiponectin increases postprandially in obese, but not in lean, subjects. Obes Res 2003; 11: 839–844.

    Article  Google Scholar 

  8. Schwartz MW, Seeley RJ . Neuroendocrine responses to starvation and weight loss. N Engl J Med 1997; 336: 1802–1811.

    Article  CAS  Google Scholar 

  9. Gavrila A, Peng CK, Chan JL, Mietus JE, Goldberger AL, Mantzoros CS . Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab 2003; 88: 2838–2843.

    Article  CAS  Google Scholar 

  10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistanceand beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–419.

    Article  CAS  Google Scholar 

  11. Newman WP, Brodows RG . Insulin action during acute starvation: evidence for selective insulin resistance in normal man. Metabolism 1983; 32: 590–596.

    Article  CAS  Google Scholar 

  12. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hascgawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y . Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20: 1595–1599.

    Article  CAS  Google Scholar 

  13. Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Chen CL, Tai TY, Chuang LM . Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 2001; 86: 3815–3819.

    Article  CAS  Google Scholar 

  14. Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, Moussa A, Mantzoros CS . Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res 2003; 11: 1048–1054.

    Article  CAS  Google Scholar 

  15. Ryan AS, Nicklas BJ, Berman DM, Elahi D . Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. Int J Obes Relat Metab Disord 2003; 27: 1066–1071.

    Article  CAS  Google Scholar 

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Acknowledgements

We would like to thank Christiane Otten and Ingrid von Lützau for their technical assistance and Cornelia Jaworski for her organizational work.

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Authors and Affiliations

  1. Department of Internal Medicine I, University of Luebeck, Luebeck, Germany

    V Merl, A Peters, W Kern, H L Fehm & B Schultes

  2. Institute of Neuroendocrinology, University of Luebeck, Luebeck, Germany

    K M Oltmanns, J Born & B Schultes

Authors
  1. V Merl
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  2. A Peters
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  3. K M Oltmanns
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  4. W Kern
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  5. J Born
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  6. H L Fehm
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  7. B Schultes
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Correspondence to B Schultes.

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Merl, V., Peters, A., Oltmanns, K. et al. Serum adiponectin concentrations during a 72-hour fast in over- and normal-weight humans. Int J Obes 29, 998–1001 (2005). https://doi.org/10.1038/sj.ijo.0802971

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