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The relation between obesity, abdominal fat deposit and the angiotensin-converting enzyme gene I/D polymorphism and its association with coronary heart disease

International Journal of Obesity volume 29, pages 78–84 (2005)Cite this article

Abstract

OBJECTIVE:

To analyse the relation between overweight, obesity and fat distribution with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene and its association with coronary heart disease (CHD).

DESIGN:

Cross-sectional, case–control study.

SUBJECTS:

A total of 185 cases (141 males) who had suffered at least one episode of CHD and 182 controls (127 males).

MEASUREMENTS:

Body mass index, waist circumference, blood pressure, plasma total cholesterol, triglycerides, HDL cholestrol and fasting glucose were measured with standard methods, genotyping the I/D polymorphism of ACE gene.

RESULTS:

Obesity and abdominal fat deposit are associated with CHD in women, but not independently. We have found an association between obesity and abdominal fat deposit with the ACE gene I/D polymorphism in subjects with CHD. Subjects with CHD and DD or ID genotypes have significantly higher prevalence of obesity and abdominal fat deposit and higher values of weight and waist circumference. In addition, the DD and ID genotypes increased crude OR of obesity. The DD and ID genotypes of the ACE gene I/D polymorphism and BMI are independently associated with CHD.

CONCLUSION:

There is a relation between the type and grade of obesity with the genotypes of the ACE gene I/D polymorphism in subjects with CHD.

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Acknowledgements

We appreciate the technical assistance of Isabel Soria Cuenca, the staff of the Clinical Biochemistry Laboratory of the University Hospital Dr Peset, and the Institute of Biomedical Investigations of Valencia. This study was supported by Grant GV97-VS-23-111 of the Generalitat Valenciana, Conselleria de Cultura Educació i Ciencia, Valencia, Spain.

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Author notes

  1. C Riera-Fortuny

    Present address: Centro Salud Xirivella, Valencia, Spain

Authors and Affiliations

  1. Hospital Universitario Dr. Peset, Valencia, Spain

    C Riera-Fortuny, M L Martínez-Triguero, C Morillas-Ariño & A Hernández-Mijares

  2. Fundación Valenciana de Investigaciones Biomédicas, Valencia, Spain

    J T Real & F J Chaves

  3. Departamento de Medicina, Universidad de Valencia, Valencia, Spain

    J T Real, C Morillas-Ariño & A Hernández-Mijares

  4. Departamento de Medicina Preventiva y Salud Pública, Universidad de Valencia, Valencia, Spain

    M Morales-Suárez-Varela

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  1. C Riera-Fortuny
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Correspondence to A Hernández-Mijares.

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Riera-Fortuny, C., Real, J., Chaves, F. et al. The relation between obesity, abdominal fat deposit and the angiotensin-converting enzyme gene I/D polymorphism and its association with coronary heart disease. Int J Obes 29, 78–84 (2005). https://doi.org/10.1038/sj.ijo.0802829

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  • DOI: https://doi.org/10.1038/sj.ijo.0802829

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