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Weight loss without losing muscle mass in pre-obese and obese subjects induced by a high-soy-protein diet


OBJECTIVE: To determine change of weight, body composition, metabolic and hormonal parameters induced by different intervention protocols.

DESIGN: Randomized, controlled study including participants exhibiting a BMI between 27.5 and 35. Three different interventions containing lifestyle education (LE-G), or a substitutional diet containing a high-soy-protein low-fat diet with (SD/PA-G) or without (SD-G) a guided physical activity program.

SUBJECTS: A total of 90 subjects (mean weight 89.9 kg; mean BMI 31.5), randomly assigned to one of three treatment groups.

MEASUREMENTS: Change in body weight, fat mass and lean body mass measured with the Bod Pod® device at baseline, 6 weeks and 6 months; change in metabolic and hormonal parameters.

RESULTS: In all, 83 subjects completed the 6-months study. BMI dropped highly significantly in all groups (LE-G: −2.2±1.43 kg/m2; SD-G: −3.1±1.29 kg/m2; SD/PA-G: −3.0±1.29 kg/m2). Subjects in the SD-G and in the SD/PA-G lost more weight during the 6-months study (−8.9±3.9; −8.9±3.9 kg) than did those in the LE-G (−6.2±4.2 kg), and had a greater decrease in fat mass (−8.8±4.27; −9.4±4.54 kg) than those in the LE-G (−6.6±4.59 kg). In contrast, no significant intraindividual or between-group changes in the fat-free mass were seen. In all groups, metabolic parameters showed an improvement in glycemic control and lipid profile.

CONCLUSIONS: Our data suggest that a high-soy-protein and low-fat diet can improve the body composition in overweight and obese people, losing fat but preserving muscle mass.

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  1. Department of Health and Human Services. The Surgeon General's call to action to prevent and decrease overweight and obesity. Government Printing Office: Washington, DC; 2001.

  2. Skov AR, Toubro S, Ronn B, Holm L, Astrup A . Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes Relat Metab Disord 1999; 23: 528–536.

    Article  CAS  Google Scholar 

  3. Layman DK, Boileau RA, Erickson DJ, Painter JE, Shiue H, Sather C, Christou DD . A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. J Nutr 2003; 133: 411–417.

    Article  CAS  Google Scholar 

  4. McGarry JD . Glucose–fatty acid interactions in health and disease. Am J Clin Nutr 1998; 67: 500S–5504.

    Article  CAS  Google Scholar 

  5. Wolfe RR . Metabolic interactions between glucose and fatty acids in humans. Am J Clin Nutr 1998; 67: 519S–5526.

    Article  CAS  Google Scholar 

  6. Wolfe BM, Giovannetti PM . Short-term effects of substituting protein for carbohydrate in the diets of moderately hypercholesterolemic human subjects. Metabolism 1991; 40: 338–343.

    Article  CAS  Google Scholar 

  7. Sidossis LS, Mittendorfer B, Walser E, Chinkes D, Wolfe RR . Hyperglycemia-induced inhibition of splanchnic fatty acid oxidation increases hepatic triacylglycerol secretion. Am J Physiol Endocrinol Metab 1998; 275: E798–E805.

    Article  CAS  Google Scholar 

  8. Foster GD, Wyatt HR, Hill JO, McGuckin BG, Brill C, Mohammed BS, Szapary PO, Rader DJ, Edman JS, Klein S . A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 2003; 348: 2082–2090.

    Article  CAS  Google Scholar 

  9. Anderson GH, Moore SE . Dietary proteins in the regulation of food intake and body weight in humans. J Nutr 2004; 134: 974S–9979.

    Article  CAS  Google Scholar 

  10. Reeds PJ, Burrin DG, Davis TA, Stoll B . Amino acid metabolism and the energetics of growth. Arch Tierernahr 1998; 51: 187–197.

    Article  CAS  Google Scholar 

  11. Parker B, Noakes M, Luscombe N, Clifton P . Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes. Diabetes Care 2002; 25: 425–430.

    Article  Google Scholar 

  12. Baba NH, Sawaya S, Torbay N, Habbal Z, Azar S, Hashim SA . High protein vs high carbohydrate hypoenergetic diet for the treatment of obese hyperinsulinemic subjects. Int J Obes Relat Metab Disord 1999; 23: 1202–1206.

    Article  CAS  Google Scholar 

  13. Whitehead JM, McNeill G, Smith JS . The effect of protein intake on 24-h energy expenditure during energy restriction. Int J Obes Relat Metab Disord 1996; 20: 727–732.

    CAS  PubMed  Google Scholar 

  14. Layman DK, Baum JI . Dietary protein impact on glycemic control during weight loss. J Nutr 2004; 134: 968S–9973.

    Article  CAS  Google Scholar 

  15. WHO. Report of the World Health Organization Consultation of Obesity. Geneva; 1997.

  16. McCrory MA, Gomez TD, Bernauer EM, Mole PA . Evaluation of a new air displacement plethysmograph for measuring human body composition. Med Sci Sports Exerc 1995; 27: 1686–1691.

    Article  CAS  Google Scholar 

  17. Ballor DL, Poehlman ET . Exercise-training enhances fat-free mass preservation during diet-induced weight loss: a meta-analytical finding. Int J Obes Relat Metab Disord 1994; 18: 35–40.

    CAS  PubMed  Google Scholar 

  18. Brodsky IG, Suzara D, Hornberger TA, Goldspink P, Yarasheski KE, Smith S, Kukowski J, Esser K, Bedno S . Isoenergetic dietary protein restriction decreases myosin heavy chain IIx fraction and myosin heavy chain production in humans. J Nutr 2004; 134: 328–334.

    Article  CAS  Google Scholar 

  19. Mikkelsen PB, Toubro S, Astrup A . Effect of fat-reduced diets on 24-h energy expenditure: comparisons between animal protein, vegetable protein, and carbohydrate. Am J Clin Nutr 2000; 72: 1135–1141.

    Article  CAS  Google Scholar 

  20. Stein TP, Donaldson MR, Leskiw MJ, Schluter MD, Baggett DW, Boden G . Branched-chain amino acid supplementation during bed rest: effect on recovery. J Appl Physiol 2003; 94: 1345–1352.

    Article  CAS  Google Scholar 

  21. Liu Z, Jahn LA, Long W, Fryburg DA, Wei L, Barrett EJ . Branched chain amino acids activate messenger ribonucleic acid translation regulatory proteins in human skeletal muscle, and glucocorticoids blunt this action. J Clin Endocrinol Metab 2001; 86: 2136–2143.

    CAS  PubMed  Google Scholar 

  22. Layman DK . The role of leucine in weight loss diets and glucose homeostasis. J Nutr 2003; 133: 261S–267S.

    Article  Google Scholar 

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Deibert, P., König, D., Schmidt-Trucksaess, A. et al. Weight loss without losing muscle mass in pre-obese and obese subjects induced by a high-soy-protein diet. Int J Obes 28, 1349–1352 (2004).

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