Table 3 Change in secondary outcomes by treatment group

From: The effect of the dietary supplement, Chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults

  Chitosan Placebo Treatment difference
Area under the curve (LOCF) a N Mean change s.e.m. N Mean change s.e.m. Mean 95% CI P-value
Body mass index (kg/m2) 125 −0.17 (0.09) 125 0.05 (0.07) 0.21 −0.02, 0.44 0.07
Waist circumference (cm) 125 −0.57 (0.30) 125 0.07 (0.28) 0.64 −0.18, 1.46 0.13
Body fat (%) 121 −0.85 (0.27) 118 −0.61 (0.19) 0.24 −0.41, 0.89 0.46
Systolic blood pressure (mmHg) 125 −2.71 (0.92) 125 −1.55 (0.98) 1.16 −1.49, 3.81 0.39
Diastolic blood pressure (mmHg) 125 −2.70 (0.55) 125 −2.68 (0.49) 0.03 −1.43, 1.49 0.97
Glucose (mmol/l) 118 −0.14 (0.05) 116 0.06 (0.05) 0.21 0.07, 0.34 <0.01
Vitamin E, (μg/l) 120 −1.15 (0.50) 119 −0.08 (0.50) 1.07 −0.32, 2.47 0.13
Vitamin A (μmol/l) 120 −0.04 (0.02) 119 0.00 (0.02) 0.04 −0.03, 0.11 0.27
Beta-carotene (μmol/l) 120 −0.02 (0.03) 118 0.03 (0.03) 0.05 −0.03, 0.14 0.21
25-OH vitamin D (nmol/l) 122 −9.00 (1.81) 121 −8.64 (1.81) 0.36 −4.68, 5.40 0.89
Prothrombin ratio 117 0.01 (0.01) 115 0.03 (0.01) 0.02 −0.02, 0.05 0.31
Faecal fat (mmol/day) 25 −0.08 (1.53) 26 0.12 (1.50) 0.20 −4.11, 4.51 0.93
  1. aAUC summary measure was used to assess the change for all end points measured at more than two time points. Change in end points that were only measured at baseline and 24 weeks (glucose, fat-soluble vitamins, faecal fat) was assessed using ANCOVA.