Table 2 Change in body weight by analysis method and treatment group

From: The effect of the dietary supplement, Chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults

  ITT (LOCF) analysis a Completers only analysis b Per protocol analysis c
  Mean change (s.e.m.) Mean change (s.e.m.) Mean change (s.e.m.)
Area under the curve Chitosan (n=125) Placebo (n=125) Treatment difference P-value Chitosan (n=78) Placebo (n=68) Treatment difference P-value Chitosan (n=44) Placebo (n=29) Treatment difference P-value
Weight (kg) −0.39 (0.21) 0.17 (0.16) 0.56 (0.26) 0.03 −0.94 (0.29) −0.05 (0.26) 0.90 (0.40) 0.03 −1.63 (0.44) −0.74 (0.49) 0.88 (0.68) 0.20
  1. aITT=intention-to-treat analysis. Missing values are assigned the last value carried forward from the previous visit.
  2. bIncludes only participants who attended all study visits.
  3. cIncludes only participants who attended all study visits and maintained ≥85% compliance throughout, as measured by capsule counts.