Abstract
OBJECTIVE: To examine the effects of a sugar-only (SO) beverage vs one containing a mixed-nutrient (MN) composition on energy expenditure and feelings of hunger and satiety.
HYPOTHESIS: A beverage containing a mixed macronutrient composition will lead to greater thermic effect of food and feelings of fullness than an isocaloric beverage containing only sugar.
RESEARCH METHODS AND PROCEDURES: Adults were randomly assigned to receive a 2510 kJ (600 kcal) SO liquid formula followed by an isovolumic, isoenergetic, MN liquid formula with an energy distribution of 17% protein, 67% carbohydrates as sucrose and corn syrup solids, and 16% fat, or vice versa, in a crossover design. The carbohydrate source in the two beverages was identical: 1:1 ratio of sucrose and corn syrup solids (25 dextrose equivalents). The thermic response was calculated as the 7 h deviation from resting metabolic rate (RMR). Subjects provided hunger/satiety ratings and other related information by visual analog scales at regular intervals throughout the study period.
RESULTS: In all, 20 subjects completed the protocol; one was removed from the thermic effect analysis due to discrepant RMRs. Following beverage ingestion, SO and MN liquid meals produced 7 h thermic effects of (X±s.e.m.) 274.1±27.6 kJ (65.5±6.6 kcal) and 372.0±33.9 kJ (88.9±8.1 kcal), respectively, resulting in a significant (P<0.01) difference between meals (Δ=97.9±35.1 kJ [23.4±8.4 kcal]). Analysis of satiety ratings using area under the curve analysis showed greater feelings of satiety (P<0.05) with MN compared to SO consumption. Also, subjects felt that they could eat less (P<0.05) after consumption of the MN vs SO beverage.
DISCUSSION: In comparison to MN beverages, SO beverages are associated with a relatively high-energy retention without accompanying subjective hunger/fullness compensations, suggesting a basis for their role in long-term unintentional weight gain in healthy adults.
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Acknowledgements
Supported by NIH grant # DK PO1-42618, a grant-in-aid from Mead Johnson Nutritional Division, and fellowship funding for M-P St-O by Bristol Myers Squibb–Mead Johnson.
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St-Onge, MP., Rubiano, F., DeNino, W. et al. Added thermogenic and satiety effects of a mixed nutrient vs a sugar-only beverage. Int J Obes 28, 248–253 (2004). https://doi.org/10.1038/sj.ijo.0802560
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DOI: https://doi.org/10.1038/sj.ijo.0802560
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