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The effect of a rapid weight loss on lipid profile and glycemic control in obese type 2 diabetic patients


OBJECTIVE: To test the effect of low calorie diet (LCD) on body weight, lipid profile, and glycemic control in obese type 2 diabetes mellitus (DM) patients.

DESIGN: Dietary intervention.

SETTING: Department of Human Nutrition, Copenhagen.

SUBJECTS: Outpatients: 11 type 2 DM patients (three males/eight females) (10 completed), four on oral hypoglycemic agents (OHA). Body mass index (BMI) 36.8±5.5 kg/m2 and age 62±5.7 y.

INTERVENTIONS: In all, 8 weeks full meal-replacement diet: eight sachets of a nutrition powder (Nutrilett®, 850 kcal/day). Lipid profile assessed by NMR spectroscopy.

RESULTS: Mean body weight fell by 10.9 kg (11%, P<0.001). Fasting insulin, fasting blood glucose, hemoglobin A1c, fasting plasma triglycerides, total cholesterol, and low-density lipoprotein (LDL) cholesterol fell significantly. There were large positive changes (statistically insignificant) in LDL subclass distribution and a similar shift in high-density lipoprotein subclass distribution. Medication was discontinued in all four subjects taking OHA for 2 weeks prior to the intervention and throughout the whole 8-week intervention period.

CONCLUSION: LCD is effective in improving glycemic control and blood lipids through weight loss in overweight type 2 DM patients.

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Correspondence to A Astrup.

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Harder, H., Dinesen, B. & Astrup, A. The effect of a rapid weight loss on lipid profile and glycemic control in obese type 2 diabetic patients. Int J Obes 28, 180–182 (2004).

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