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Medium- versus long-chain triglycerides for 27 days increases fat oxidation and energy expenditure without resulting in changes in body composition in overweight women


OBJECTIVE: To determine the effects of long-term consumption of medium chain (MCT) versus long chain triglycerides (LCT) on energy expenditure (EE), substrate oxidation and body composition.

HYPOTHESIS: MCT consumption will not result in greater EE, substrate oxidation, and body weight loss compared with LCT consumption.

RESEARCH METHODS AND PROCEDURES: Seventeen healthy obese women participated in this randomized, crossover inpatient trial. Meals were prepared and consumed on site for two periods of 27 days. Diets containing 40% of energy as fat, with treatment fat comprising 75% of the total fat, were designed to supply each subject with their individual weight-maintaining energy needs. The MCT diet contained 67% of treatment fat as MCT oil (49% octanoate, 50% decanoate) whereas the LCT diet contained exclusively beef tallow as treatment fat. Body composition was assessed by magnetic resonance imaging (MRI) on day 1 and 28 of each phase while energy expenditure was measured on day 2 and 27.

RESULTS: Changes in total and subcutaneous adipose tissue volumes following consumption of MCT and LCT were not different (−0.61±0.38 l vs −0.54±0.48 l and −0.58±0.35 l vs −0.48±0.40 l, respectively). Average EE and fat oxidation were greater (P<0.05) during MCT than LCT consumption (0.95±0.019 vs 0.90±0.024 kcal/min, respectively, for EE and 0.080±0.0026 vs 0.075±0.0022 g/min, respectively for fat oxidation).

DISCUSSION: These results show that long-term consumption of MCT enhances EE and fat oxidation in obese women, when compared to LCT consumption. The difference in body composition change between MCT and LCT consumption, although not statistically different, was consistent with differences predicted by the shifts in EE. It can be concluded that substitution of MCT for LCT in a targeted energy balance diet may prevent long-term weight gain via increased EE.

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  1. Crozier G, Bois-Joyeux B, Chanez M, Girard J & Peret J . Metabolic effects induced by long-term feeding of medium-chain triglycerides in the rat. Metabolism 1987; 36: 807–814.

    Article  CAS  PubMed  Google Scholar 

  2. Geliebter A, Torbay N, Bracco EF, Hashim SA & Van Itallie TB . Overfeeding with medium-chain triglyceride diet results in diminished deposition of fat. Am J Clin Nutr 1983; 37: 1–4.

    Article  CAS  PubMed  Google Scholar 

  3. Hashim SA & Tantibhedyangkul P . Medium chain triglyceride in early life: effects on growth of adipose tissue. Lipids 1987; 22: 429–434.

    Article  CAS  PubMed  Google Scholar 

  4. Baba N, Bracco F & Hashim SA . Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with diet containing medium chain triglyceride. Am J Clin Nutr 1982; 35: 678–682.

    Article  CAS  PubMed  Google Scholar 

  5. Lasekan JB, Rivera J, Hirvonen MD, Keesey RE & Ney DM . Energy expenditure in rats maintained with intravenous or intragastric infusion of total parenteral nutrition solutions containing medium- or long-chain triglyceride emulsions. J Nutr 1992; 122: 1483–1492.

    Article  CAS  PubMed  Google Scholar 

  6. Rothwell NJ & Stock MJ . Stimulation of thermogenesis and brown fat activity in rats fed medium chain triglyceride. Metabolism 1987; 36: 128–130.

    Article  CAS  PubMed  Google Scholar 

  7. Dulloo AG, Fathi M, Mensi N & Girardier L . Twenty-four-hour energy expenditure and urinary catecholamines of humans consuming low-to-moderate amounts of medium-chain triglycerides: a dose-response study in a human respiratory chamber. Eur J Clin Nutr 1996; 50: 152–158.

    CAS  PubMed  Google Scholar 

  8. Seaton TB, Welle SL, Warenko MK & Campbell RG . Thermic effect of medium-chain and long-chain triglycerides in man. Am J Clin Nutr 1986; 44: 630–634.

    Article  CAS  PubMed  Google Scholar 

  9. Scalfi L, Coltorti A & Contaldo F . Postprandial thermogenesis in lean and obese subjects after meals supplemented with medium-chain and long-chain triglycerides. Am J Clin Nutr 1991; 53: 1130–1133.

    Article  CAS  PubMed  Google Scholar 

  10. White M, Papamandjaris AA & Jones PJH . Enhanced postprandial energy expenditure with medium-chain fatty acid feeding is attenuated after 14 d in premenopausal women. Am J Clin Nutr 1999; 69: 883–889.

    Article  CAS  PubMed  Google Scholar 

  11. Hill JO, Peters JC, Yang D, Sharp T, Kaler M, Abumrad NN & Greene HL . Thermogenesis in humans during overfeeding with medium-chain triglycerides. Metabolism 1989; 38: 641–648.

    Article  CAS  PubMed  Google Scholar 

  12. Papamandjaris AA, White MD & Jones PJH . Components of total energy expenditure in healthy young women are not affected after 14 days of feeding with medium- versus long-chain triglycerides. Obes Res 1999; 7: 273–280.

    Article  CAS  PubMed  Google Scholar 

  13. Tsuji H, Kasai M, Takeucchi H, Nakamura M, Okazaki M & Kondo K . Dietary medium-chain triacylglycerols suppress accumulation of body fat in a double-blind, controlled trial in healthy men and women. J Nutr 2001; 131: 2853–2859.

    Article  CAS  PubMed  Google Scholar 

  14. Mifflin MD, St-Jeor ST, Hill LA, Scott BJ, Daugherty SA & Koh YO . A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 1990; 51: 241–247.

    Article  CAS  PubMed  Google Scholar 

  15. Bell L, Jones PJH, Telch J, Clandinin MT & Pencharz PB . Prediction of energy needs for clinical studies. Nutr Res 1985; 5: 123–129.

    Article  Google Scholar 

  16. Bourque C, St-Onge M-P, Papamandjaris AA, Cohn JS & Jones PJH . Consumption of a functional oil composed of medium chain triacylglycerols, phytosterols and n-3 fatty acids improves the overall cardiovascular risk profile of overweight women. Submitted for publication, 2002.

  17. Ross R, Rissanen J, Pedwell H, Clifford J & Shragge P . Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men. J Appl Physiol 1996; 81: 2445–2455.

    Article  CAS  PubMed  Google Scholar 

  18. Lusk G . The elements of the science of nutririon. WB Saunders Co: Philadelphia; 1928.

  19. Katch F & McArdle W (eds) . Nutrition, weight control, and exercise, Lea and Febiger: Philadelphia; 1993.

    Google Scholar 

  20. Groff JL & Gropper SS . Advanced nutrition and human metabolism, Wadsworth Thomson Learning: Belmont; 2000.

    Google Scholar 

  21. Folch J, Lees M & Stanley GHS . A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497–509.

    CAS  PubMed  Google Scholar 

  22. Ross R . Magnetic resonance imaging provides new insights into the characterization of adipose and lean tissue distribution. Can J Physiol Pharmacol 1996; 74: 778–785.

    Article  CAS  PubMed  Google Scholar 

  23. Thomas LE, Saeed N, Hajnal JV, Brynes A, Goldstone AP, Frost G & Bell JD . Magnetic resonance imaging of total body fat. J Appl Physiol 1998; 85: 1778–1785.

    Article  CAS  PubMed  Google Scholar 

  24. Ross R, Leger L, Morris D, de Guise J & Guardo R . Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol 1992; 72: 787–795.

    Article  CAS  PubMed  Google Scholar 

  25. Ross R, Shaw KD, Martel Y, de Guise M & Avruch L . Adipose tissue distribution measured by magnetic resonance imaging in obese women. Am J Clin Nutr 1993; 57: 470–475.

    Article  CAS  PubMed  Google Scholar 

  26. Mitsiopoulos N, Baumgartner RN, Lyons W, Heymsfield SB, Gallagher D & Ross R . Cadaver validation of magnetic resonance imaging and computerized tomography measurement of human skeletal muscle. J Appl Physiol 1998; 85: 115–122.

    Article  CAS  PubMed  Google Scholar 

  27. Sevenhuysen GP, Fieldhouse P, Young TX, McNeil C, Gelskey DE & McDonald SM . The Manitoba Nutrition Survey: fat consumption data. Can J Pub Health 1993; 84: 389–393.

    CAS  Google Scholar 

  28. Hyvonen L, Lampi AM, Varo P & Kavistoinen O . Fatty acid analysis, TAG equivalents as net fat value, and nutritional attributes of commercial fats and oils. J Food Compos Anal 1993; 6: 24–40.

    Article  CAS  Google Scholar 

  29. Binnert C, Pachiaudi C, Beylot M, Hans D, Vandermander J, Chantre P, Riou J-P & Laville M . Influence of human obesity on the metabolic fate of dietary long- and medium-chain triacylglycerols. Am J Clin Nutr 1998; 68: 595–601.

    Article  Google Scholar 

  30. Gasic S, Schneider B & Waldhausl W . Indirect calorimetry: variability of consecutive baseline determinations of carbohydrate and fat utilization from gas exchange measurements. Horm Metab Res 1997; 29: 12–15.

    Article  CAS  PubMed  Google Scholar 

  31. Lia A, Andersson H, Mekki N, Juhel C, Senft M & Lairon D . Postprandial lipemia in relation to sterol and fat excretion in ileostomy subjects given oat bran and wheat test meals. Am J Clin Nutr 1997; 66: 357–365.

    Article  CAS  PubMed  Google Scholar 

  32. Calloway DH, Kurtz GW, McCullen JJ & Thomas LV . The absorbability of natural and modified fats. Food Res 1956; 21: 621–629.

    Article  CAS  Google Scholar 

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We would like to thank Dr Andrea Papamandjaris, Chris Vanstone, Andrea D'Souza, Erika Motoie and Sarah Miller for their technical assistance and all subjects for participating in this trial. Funding was provided by Dairy Farmers of Canada and Forbes Medi-Tech Inc.

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Correspondence to P J H Jones.

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St-Onge, MP., Bourque, C., Jones, P. et al. Medium- versus long-chain triglycerides for 27 days increases fat oxidation and energy expenditure without resulting in changes in body composition in overweight women. Int J Obes 27, 95–102 (2003).

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