Abstract
OBJECTIVES: We present a novel method of scanning for intra-abdominal fat volume by helical computed tomography (CT), and describe the clinical significance of measuring the volumes of intra-abdominal visceral fat (Vvol) and subcutaneous fat (Svol) vs these respective areas determined by conventional slice-by-slice CT at the umbilical level.
METHOD: Subjects with obesity or hyperlipidemia (79 men, 74 women) were recruited for this study. We obtained helical CT scans with a tube current of 150 mA, voltage of 120 kV and 2:1 pitch (table speed in relation to slice thickness), starting at the upper edge of the liver and continuing until the pelvis. The intra-abdominal visceral fat volume was measured by drawing a line within the muscle wall surrounding the abdominal cavity. The abdominal subcutaneous fat volume was calculated by subtracting the visceral fat volume from the total abdominal fat volume. By comparison, the intra-abdominal visceral and subcutaneous fat areas were determined at the umbilical level by the established slice-by-slice CT scanning technique.
RESULTS: Vvol was correlated positively with visceral fat area (Varea) measured by conventional CT in both genders (in men (n=79) Vvol vs Varea, r=0.81 P<0.0001; in women (n=74) Vvol vs Varea, r=0.85, P<0.0001). Svol also showed a positive correlation with subcutaneous fat area (Sarea) in both genders (in men (n=78) Svol vs Sarea, r=0.95, P<0.0001; in women (n=74) Svol vs Sarea, r=0.92, P<0.0001).
CONCLUSION: We have reported a novel method for measuring intra-abdominal fat volume by the use of helical CT.
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References
Kalender WA, Polacin A . Physical performance characteristics of spiral CT scanning Med Phys 1991 18: 910–915.
Rigaus H, Marchal G, Baert AL, Hupke R . Spiral scanning and the influence of the reconstruction algorithm on image quality J Comput Assist Tomogr 1990 14: 675–682.
Heiken JP, Brink JA, Vannier MW . Spiral (helical) CT Radiology 1993 189: 647–656.
Zeman RK, Fox SH, Silverman PM, Davros WJ, Carter LM, Griego D, Weltman DI, Ascher SM, Cooper CJ . Helical (spiral) CT of the abdomen Am J Roentgenol 1993 160: 719–725.
Rogalla P, Meiri N, Hoksch B, Boeing H, Hamm B . Low-dose spiral computed tomography for measuring abdominal fat volume and distribution in a clinical setting Eur J Clin Nutr 1998 52: 597–602.
Vague J . The degree of masculine differentiation of obesities, a factor determining predisposition to diabetes, atherosclerosis, gout and uric calculous disease Am J Clin Nutr 1956 4: 20–34.
Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S . A novel technique for the determination of body fat by computed tomography Int J Obes 1983 7: 437–445.
Taira K, Hikita M, Kobayashi J, Bujo H, Takahashi K, Murano S, Morisaki N, Saito Y . Delayed post-prandial lipid metabolism in subjects with intra-abdominal visceral fat accumulation Eur J Clin Invest 1999 29: 301–308.
Couillard C, Bergeron N, Prud'homme D, Bergeron J, Tremblay A, Bouchard C, Mauriege P, Després JP . Postprandial triglyceride response in visceral obesity in men Diabetes 1998 47: 953–960.
Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Björntorp P, Tibblin G . Abdominal adopose tissue distribution, obesity and risk of cardiovascular disease and death: 13 y follow up of participants in the study of men born in 1913 Br Med J Clin Res 1984 288: 1401–1404.
Spiegelman BM, Flier JS . Adipogenesis and obesity: rounding out the big picture Cell 1996 87: 377–389.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM . Positional cloning of the mouse obese gene and its human homologue Nature Med 1994 372: 425–432.
Friedman JM, Halaas JL . Leptin and the regulation of body weight in mammals Nature 1998 395: 763–770.
Monitat M, Deng C, Muzzin P . Assimacopoulos-Jeannet F, Seydoux J, Dulloo AG, Giacobino JP. Modulation of obese gene expression in rat brown and white adipose tissues FEBS Lett 1995 373: 131–134.
Leroy P, Dessolin S, Villageois P, Moon BC, Frieman JM, Ailhaud G, Dani C . Expression of ob gene in adipose cells. Regulation by insulin J Biol Chem 1996 271: 2365–2368.
Hwa JJ, Fawzi AB, Graziano MP, Ghibaudi L, WIlliams P, Van Heek M, Davis H, Rudinski M, Sybertz E, Strader CD . Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice Am J Physiol 1997 272: R1204–1209.
Ryan AS, Elahi D . The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women J Clin Endocrinol Metab 1996 81: 4433–4438.
Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Rangathan S, Kern PA, Friedman JM . Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Nature Med 1995 1: 1155–1161.
Dua A, Hennes MI, Hoffmann RG, Maas DL, Krakower GR, Sonnenberg GE, Kissebah AH . Leptin: a significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women Diabetes 1996 45: 1635–1637.
Banerji MA, Faridi N, Atluri R, Chaiken RL, Lebovitz HE . Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men J Clin Endocrinol Metab 1999 84: 137–144.
Ronnemaa T, Kronen SL, Rissanen A, Koskenvno M, Koivisto VA . Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity Ann Intern Med 1997 126: 26–31.
Zhongmin M, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M . Radioimmunoassay of leptin in human plasma Clin Chem 1996 42: 942–946.
Ross R, Leger L, Morris D, de Guise J, Guardo R . Quantification of adiopose tissue by MRI: relationship with anthropometric variables J Appl Physiol 1992 72: 787–795.
Ross R, Shaw KD, Martel Y, deGuise J, Avruch L . Adipose tissue distribution measured by magnetic resonance imaging in obese women Am J Clin Nutr 1993 57: 470–475.
Lonnqvist F, Arner P, Nordfors L, Schalling M . Overexpression of the obese (ob) gene in adipose tissue of human obese subjects Nature Med 1995 1: 953–956.
Considine RV, Sinha M, Heiman ML, Kriauciunos A, Stephens TW, Nyce MR, Phannesian JP, Marco CC, Mcker LJ, Bauer TL, Caro JF . Serum immunoreactive leptin concentrations in normal weight and obese humans New Engl J Med 1996 334: 292–295.
Ramchandaran A, Snehalatha C, Vijay K, Styavani E, Latha S, Haffner SM . Plasma leptin in non-diabetic Asian Indians: association with abdominal adiposity Diabetic Med 1997 14: 937–941.
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Kobayashi, J., Tadokoro, N., Watanabe, M. et al. A novel method of measuring intra-abdominal fat volume using helical computed tomography. Int J Obes 26, 398–402 (2002). https://doi.org/10.1038/sj.ijo.0801921
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DOI: https://doi.org/10.1038/sj.ijo.0801921
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