Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Regulation of appetite: role of leptin in signalling systems for drive and satiety

Abstract

BACKGROUND: The healthy regulation of appetite involves a balance between excitatory (drive) and inhibitory (satiety) processes. For many years research has concentrated on the identification of signalling systems that mediate satiety to the relative exclusion of drive-inducing biological events. However, the so-called long-term regulation of body weight has recently been given substance by the identification of a chemical signal believed to link the brain with adipose tissue stores.

ANALYSIS: This signal, leptin, is in position to modulate the expression of a drive to eat. Studies on the relationship between leptin and perceived hunger, and on the eating behaviour of leptin-deficient individuals, are consistent with the intervention of leptin in a drive system. The contrast between the roles of leptin and serotonin in appetite regulation reflects the difference between drive-signalling and satiety signalling processes.

CONCLUSION: It is proposed that leptin modulates the drive signals arising from the metabolic demand for energy but also shows some properties of a post-prandial satiety signal.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to JE Blundell.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Blundell, J., Goodson, S. & Halford, J. Regulation of appetite: role of leptin in signalling systems for drive and satiety. Int J Obes 25, S29–S34 (2001). https://doi.org/10.1038/sj.ijo.0801693

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ijo.0801693

Keywords

  • satiety
  • drive
  • appetite
  • leptin
  • food intake

Further reading

Search

Quick links