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Value of VLCD supplementation with medium chain triglycerides

International Journal of Obesity volume 25, pages 1393–1400 (2001)Cite this article

Abstract

BACKGROUND: Medium chain triglycerides (MCT) are energetically less dense, highly ketogenic, and more easily oxidised than long chain triglycerides (LCT). MCT also differ from LCT in their digestive and metabolic pathways.

OBJECTIVE: To test the effects of MCT supplementation during a very low calorie diet (VLCD).

SUBJECTS AND METHODS: Three groups of tightly matched obese women with body mass index (BMI)>30 kg/m2 received an isoenergetic (578.5 kcal) VLCD (Adinax®, Novo Vital, Sweden) enriched with MCT or LCT (8.0 and 9.9 g/100 g Adinax® respectively) or a low-fat (3 g/100 g) and high-carbohydrate regimen. The diets were administered over 4 weeks. Body composition was measured with DEXA and appetite/satiety-according to Blundell. Beta hydroxybutyric acid concentration in plasma and nitrogen excretion in urine was measured during consecutive days of VLCD. The study was performed in a randomised double-blind manner.

RESULTS: The MCT group showed a significantly greater decrease in body weight during the first 2 weeks. The contribution of body fat to the total weight loss was higher while the contribution of fat-free mass (FFM) was lower. The MCT group had a higher concentration of ketone bodies in plasma and a lower nitrogen excretion in urine. Hunger feelings were less intense while satiety was higher. These differences were observed during the first 2 weeks of treatment and gradually declined during the third and fourth weeks.

CONCLUSIONS: Replacement of LCT by MCT in the VLCD increased the rate of decrease of body fat and body weight and has a sparing effect on FFM. The intensity of hunger feelings was lower and paralleled the higher increase of ketone bodies. These effects gradually declined, indicating subsequent metabolic adaptation. Further studies are required to confirm the protein-sparing and appetite-suppressing effects of MCT supplementation during the first 2 weeks of VLCD treatment.

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References

  1. Stunkard AJ, McClaren-Hume M . The results of treatment of obesity Arch Intern Med 1959 103: 79–85.

    Article  CAS  Google Scholar 

  2. Atkinson RL . Low and very low calorie diets Med Clin N Am 1989 73: 203–215.

    Article  CAS  Google Scholar 

  3. Evans FA, Strong JM . A departure from the usual methods of treating obesity Am J Med Sci 1929 177: 339–348.

    Article  Google Scholar 

  4. Howard AN . The historical development of very low calorie diet Int J Obes 1989 13: (Suppl 2): 1–9.

    Google Scholar 

  5. Wadden TS, Van Itallie TB, Blacburn GC . Responsible and irresponsible use of very low calorie diets in the treatment of obesity JAMA 1990 263: 83–85.

    Article  CAS  Google Scholar 

  6. Ryde SIS, Saunders NH, Birks JL, Ali PA, Thomas DW, Morgan VD, Evans CJ, Al-Zeibak A, Dutton J, Sivyer A . The effects of VLCD on body composition. In: Krietzman SN, Howard AN (eds). The Swansea trial. Smith Gordon: London 1993 31–54.

    Google Scholar 

  7. Hoffer LJ, Bistrian BR, Young VR, Blackburn GL, Matthews DE . Metabolic effects of very low calorie weight reduction diets J Clin Invest 1982 73: 750–758.

    Article  Google Scholar 

  8. Baba N, Bracco EF, Hashim SA . Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with a diet containing medium chain triglycerides Am J Clin Nutr 1982 35: 678–682.

    Article  CAS  Google Scholar 

  9. Bach AC, Babayan VK . Medium chain triglycerides. An update Am J Clin Nutr 1982 36: 950–962.

    Article  CAS  Google Scholar 

  10. Yeh YY, Zee P . Relation of ketosis to metabolic changes induced by acute medium chain triglycerides feeding, in rats J Nutr 1973 160: 58–67.

    Google Scholar 

  11. Binnart CH, Pachiandi CH, Beylot M, Hans D, Vandermander J, Chantre Ph, Riou JP, Laville M . Influence of human obesity on the metabolic fate of dietary long and medium chain triglycerides Am J Clin Nutr 1998 67: 595–601.

    Article  Google Scholar 

  12. Yost TJ, Eckel RH . Hypoenergy feeding in obese women. Metabolic effects of medium chain triglycerides substitution Am J Clin Nutr 1989 49: 326–330.

    Article  CAS  Google Scholar 

  13. Geliebter A, Torboy N, Bracco FE, Hashim SA, Van Itallie TB . Overfeeding with medium chain triglyceride diet results in diminished deposition of fat Am J Clin Nutr 1983 37: 1–4.

    Article  CAS  Google Scholar 

  14. Rothwell NJ, Stock MJ . Stimulation of thermogenesis and brown fat activity in rats fed medium chain triglyceride Metabolism 1987 36: 128–130.

    Article  CAS  Google Scholar 

  15. Seaton TB, Welle SL, Warenko MK, Campbell RG . Thermic effect of medium chain and long chain triglycerides in man Am J Clin Nutr 1986 44: 630–684.

    Article  CAS  Google Scholar 

  16. Scalfi L, Coltorti A, Contaldo F . Postprandial thermogenesis in lean and obese subjects after meals supplemented with medium chain and long chain triglycerides Am J Clin Nutr 1991 53: 1130–1133.

    Article  CAS  Google Scholar 

  17. Papaniandjaris AA, MacDougall DE, Jones PJH . Medium chain fatty acid metabolism and energy expenditure. Obesity treatment implications Life Sci 1998 62: 1203–1215.

    Article  Google Scholar 

  18. Kaunitz H, Slanetz CA, Johnson RE, Babayan VK, Barsky G . Relation of saturated, medium and long chain triglycerides to growth, appetite, thirst and weight maintenance requirements J Nutr 1958 64: 513–524.

    Article  CAS  Google Scholar 

  19. Krotkiewski M, Landin K, Mellström D, Tölli J . Loss of total body potassium during rapid weight loss does not depend on the decrease of potassium concentration in muscles. Different methods to evaluate body composition during a low energy diet Int J Obes Relat Metab Disord 1999 23: 1–7.

    Article  Google Scholar 

  20. Krotkiewski M, Björntorp P, Sjöström L, Smith U . Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution J Clin Invest 1983 72: 1150–1162.

    Article  CAS  Google Scholar 

  21. Bergmeyer FW . Methods of enzymatic analysis, 2nd edn. Academic Press: New York 1974.

    Chapter  Google Scholar 

  22. Hill AJ, Blundell JE . Macro-nutrients and satiety. The effects of a high protein or a high carbohydrate meal on subjective motivation to eat and food preferences Nutr Behav 1986 3: 133–144.

    Google Scholar 

  23. Blundell JE, Burley VJ . Satisfaction, satiety and the action of dietary fibre on food intake Int J Obes 1987 11(Suppl): S9–S25.

    Google Scholar 

  24. Di Gorcio J . Non-protein nitrogenous contribents. In: Henry RJ, Cannon DC, Winkelman JW (eds). Clinical chemistry. Principles and techniques Harper & Row: Hagerstown 1974 pp 503–563.

    Google Scholar 

  25. Elia M, Stubbs RJ, Henry CJK . Differences in fat, carbohydrate and protein metabolism between lean and obese subjects undergoing total starvation Obes Res 1999 7: 597–604.

    Article  CAS  Google Scholar 

  26. Peters JC, Holcombe BN, Hiller LK, Webb DR . Absorption and calorie value in adult humans J Am Coll Toxicol 1991 10: 357–367.

    Article  CAS  Google Scholar 

  27. Dullo AG, Fathi M, Mensi N, Girardier L . Twenty-four energy expenditure and urinary catecholamines of humans consuming low fat to moderate amounts of medium chain triglycerides. A dose–response study in human respiratory chamber Eur J Clin Nutr 1996 50: 152–188.

    Google Scholar 

  28. Hill JO, Peters JC, Yang D, Sharp T, Kaler M, Abumrad NN, Greene HL . Thermogenesis in man during overfeeding with medium chain triglycerides Metabolism 1989 38: 641–648.

    Article  CAS  Google Scholar 

  29. Flatt JP, Ravussin E, Acheson KJ, Jéquier E . Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balance J Clin Invest 1985 76: 1019–1024.

    Article  CAS  Google Scholar 

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  1. Department of Medical Rehabilitation, Sahlgrenska University Hospital, Göteborg, Sweden

    M Krotkiewski

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Krotkiewski, M. Value of VLCD supplementation with medium chain triglycerides. Int J Obes 25, 1393–1400 (2001). https://doi.org/10.1038/sj.ijo.0801682

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