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A twin study of weight loss and metabolic efficiency

Abstract

OBJECTIVE: To assess the genetic contribution to determinants of therapeutic weight loss in obese female identical twins.

DESIGN: Subjects were studied for 40 days on an inpatient unit in three phases: 7 baseline days; 28 days of weight reduction by a very low calorie diet (1.6 MJ per day); and 5 days after weight reduction.

SUBJECTS: Fourteen pairs of premenopausal obese female identical twins (age: 39.0±1.7 y; body weight (BW): 93.9±21.2 kg; body mass index (BMI): 34.2±7.8 kg/m2).

MEASUREMENTS: Body composition by hydrodensitometry and resting metabolic rate by indirect calorimetry were assessed before and after weight loss.

RESULTS: There was great variability among pairs in loss of weight (5.9–12.4 kg) and body fat (3.1–12.4 kg). By contrast, the intraclass correlation (ICC) within twin pairs was 0.85, P<0.001 for weight and 0.88, P<0.001 for body fat. A measure of metabolic efficiency, calculated as the difference between ‘estimated’ and ‘measured’ energy deficit showed high intrapair correlation (ICC=0.77; P<0.001).

CONCLUSIONS: The high correlation in metabolic efficiency within twin pairs in response to therapeutic weight loss suggests a strong genetic contribution.

International Journal of Obesity (2001) 25, 533–537

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References

  1. Wadden TA, Foster GD, Wang J, Pierson RN, Yang MU, Moreland K, Stunkard AJ, Vanltallie TB . Clinical correlates of short- and long-term weight loss Am J Clin Nutr 1992 56: 271S–274S.

    Article  CAS  Google Scholar 

  2. Welster JD, Garrow JS . Weight loss in 108 obese women on a diet supplying 800 kcal for 21 days Am J Clin Nutr 1989 50: 41–50.

    Article  Google Scholar 

  3. Garrow JS, Durrant ML, Mann S, Stally SF, Warwick PM . Factors determining weight loss in obese patients on a metabolic ward Int J Obes 1978 21: 441–447.

    Google Scholar 

  4. Wilson JT . Psychological prognostic factors in the treatment of obesity. In: Van Itallie TB, Hirsh J (eds) Recent advances in obesity research: IV John Libbey: London 1989 301–311.

    Google Scholar 

  5. Berchtold P, Van Itallie TB . Physiological prognistic factors for the treatment of obesity. In: Van Itallie TB, Hirsh J (eds) Recent advances in obesity research: IV John Libbey: London 1989 pp 320–326.

    Google Scholar 

  6. Leibel RL, Hirsch J . Diminished energy requirements in reduced-obese patients Metabolism 1984 33: 164–170.

    Article  CAS  Google Scholar 

  7. Ravussin E, Lillioja S, Knowler WC, Christin L, Freymond D, Abbott WG, Boyce V, Howard BV, Bogardus C . Reduced rate of energy expenditure as a risk factor for body-weight gain New Engl J Med 1988 318: 467–472.

    Article  CAS  Google Scholar 

  8. Canolty NL, Koong LF . Utilization of energy for maintenance and for fat and lean gains by mice selected for rapid postweaning growth rate J Nutr 1976 106: 1202–1208.

    Article  CAS  Google Scholar 

  9. Ferrell CL, Jenkins TG . Energy utilization by mature, nonpregnant nonlactating cows of different types J Anim Sci 1984 58: 234–243.

    Article  CAS  Google Scholar 

  10. Koong LJ, Nienaber JA, Mersmann HJ . Effect of plane of nutrition on organ size and fasting heat production in genetically obese and lean pigs J Nutr 1983 113: 1626–1631.

    Article  CAS  Google Scholar 

  11. Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, Duussuault J, Moorjani S, Pinault S, Fournier G . The response to long-term overfeeding in identical twins New Engl J Med 1990 322: 1477–1482.

    Article  CAS  Google Scholar 

  12. Bouchard C, Tremblay A, Despres JP, Theriault G, Nadeau A, Lupien PJ, Moorjani S, Prud'homme D, Fournier G . The response to exercise with constant energy intake in identical twins Obes Res 1994 2: 400–410.

    Article  CAS  Google Scholar 

  13. Hainer V, Stunkard AJ, Kunesova M, Parizkova J, Stich V, Allison, D . Genetic influences on weight loss of 14 pairs of obese female identical twins Int J Obes Relat Metab Disord 2000 24: 1051–1057.

  14. Hainer V, Kunesova M, Stich V, Parizkova J, Zak A, Wernischova V, Kozich P, Hrabak P, Dedicova L . Very low energy formula diet in the treatment of obesity Int J Obes 1989 13 (Suppl 2): 185–188.

    PubMed  Google Scholar 

  15. Hainer V, Stich V, Kunesova M, Parizkova J, Zak A, Wernischova V, Stukavec V . Body fat distribution, metabolic and hormonal indices in obese patients treated initially by very low calorie diet. In Romsos DR, Himms-Hagen J and Suzuki M (eds). Obesity: dietary factors and control Japan Scientific Press: Tokyo; and Karger: Basel 1991 215–226.

    Google Scholar 

  16. Energy and protein requirements Report of a Joint FAO/WHO/UNU Expert Consultation, Technical Report Series no. 724 WHO: Geneva 1985 76.

  17. Shroutt PE, Fleiss JL . Intraclass correlation uses in assessing rater ability Psychol Bull 1979 86: 420–428.

    Article  Google Scholar 

  18. Sweeney ME, Hill JO, Heller PA, Baney R, DiGiralamo . Severe vs moderate energy restrictions with and without exercise in the treatment of obesity: efficiency of weight loss Am J Clin Nutr 1993 57: 127–134.

    Article  CAS  Google Scholar 

  19. Levine JA, Eberhardt NL, Jensen MD . Role of nonexercise activity thermogenesis in resistance to fat gain in humans Science 1999 283: 212–214.

    Article  CAS  Google Scholar 

  20. Grilo CM, Pogue-Geile MF . The natures of environmental influences on weight and obesity: a behavioral genetic analysis Psychol Bull 1991 110: 520–537.

    Article  CAS  Google Scholar 

  21. Maes HM, Neale MC, Eaves LJ . Genetic and environmental factors in relative body weight and human adiposity Behav Genet 1997 27: 325–351.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported in part by grants IGA MZ CR 6-4311-3 from the Czech Ministry of Health, the Danone Institute and RO3-TW-00561-01 from the NIH.

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Hainer, V., Stunkard, A., Kunešová, M. et al. A twin study of weight loss and metabolic efficiency. Int J Obes 25, 533–537 (2001). https://doi.org/10.1038/sj.ijo.0801559

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  • DOI: https://doi.org/10.1038/sj.ijo.0801559

Keywords

  • obesity
  • twins
  • weight reduction
  • metabolic efficiency
  • resting metabolic rate
  • genetics

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