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Effects of weight variability on cardiovascular risk factors; a study of nonsmoking Japanese male office workers

International Journal of Obesity volume 24, pages 1226–1230 (2000)Cite this article

Abstract

OBJECTIVE: To determine the effects of weight variability on cardiovascular risk factors.

DESIGN: Longitudinal study (followed from 1990 to 1998).

SUBJECTS: Five-hundred and eighty nonsmoking Japanese male office workers aged 25–49 y.

MEASUREMENTS: Baseline levels and slopes of seven selected cardiovascular risk factors (systolic and diastolic blood pressure, total and high-density lipoprotein cholesterol, triglyceride, uric acid and hemoglobin A1c) and body mass index (BMI) variables (baseline BMI, BMI-slope, the root mean square error (BMI-RMSE), and the BMI-slope×BMI-RMSE interaction).

RESULTS: From the multiple regression analyses, the slopes of the six cardiovascular risk factors, except hemoglobin A1c, were most strongly related to the baseline level of each cardiovascular risk factor and BMI-slope. Neither BMI-RMSE nor the interaction of BMI-RMSE with BMI-slope was related to these cardiovascular risk factor slopes. As for hemoglobin A1c, BMI-slope and the interaction of BMI-RMSE with BMI-slope were not significantly related to hemoglobin A1c slope but baseline BMI and BMI-RMSE were. Furthermore, hemoglobin A1c slope values were significantly higher among those who cycled at >4.0 kg than among those who did not.

CONCLUSION: The only cardiovascular risk factor associated with BMI variability was hemoglobin A1c. Weight variability had less or little impact on cardiovascular risk factors compared with BMI-slope and baseline BMI.

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Acknowledgements

We would like to express our appreciation of all the employees and the Medical Office of the Osaka Main Office of Takenaka Corporation for their valuable cooperation for this study. We are also grateful to Ryuichi Kaneko and his colleagues at the Japan Labor and Welfare Association for collecting and coding the data accurately and consistently over a period of 8 y.

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Authors and Affiliations

  1. Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Osaka, Japan

    N Nakanishi & K Tatara

  2. Medical Office, Osaka Main Office, Takenaka Corporation, Japan

    K Nakamura

  3. Japan Labor and Welfare Association, Japan

    K Suzuki

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  1. N Nakanishi
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  2. K Nakamura
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  3. K Suzuki
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  4. K Tatara
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Nakanishi, N., Nakamura, K., Suzuki, K. et al. Effects of weight variability on cardiovascular risk factors; a study of nonsmoking Japanese male office workers. Int J Obes 24, 1226–1230 (2000). https://doi.org/10.1038/sj.ijo.0801389

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