Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Paper
  • Published:

oCRF and CRF (6-33) depress food but not water intake in the obese Zucker rat

International Journal of Obesity volume 24, pages S140–S141 (2000)Cite this article

Abstract

It has previously been demonstrated that oCRF and the CRF binding protein inhibitor CRF (6-33) reduce body-weight gain in obese Zucker rats. We investigated whether the reduction in body-weight is attributable to altered feeding and drinking behaviour. Obese Zucker rats were fitted with osmotic mini-pumps connected to i.c.v. cannulas. Vehicle, oCRF (5 μg/day) or CRF (6-33) (25 μg/day) were infused for 7 days and the animals observed for an additional 7 days. Body-weight and food and water-intake were recorded daily at 14.00 h. In agreement with published results, oCRF and CRF (6-33) significantly reduced body-weight gain in the obese Zucker rat. In addition, food intake was reduced, whereas water consumption was unaffected.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Health Care Discovery and Preclinical Development, Novo Nordisk, Måløv, Denmark

    CA Bjenning & K Rimvall

Authors
  1. CA Bjenning
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K Rimvall
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to CA Bjenning.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bjenning, C., Rimvall, K. oCRF and CRF (6-33) depress food but not water intake in the obese Zucker rat. Int J Obes 24 (Suppl 2), S140–S141 (2000). https://doi.org/10.1038/sj.ijo.0801304

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ijo.0801304

Keywords

Search

Advanced search

Quick links