Abstract
OBJECTIVE: To assess the relationships between the regulation of diurnal and food-induced cortisol secretion and anthropometric, metabolic and haemodynamic variables in middle-aged men.
SUBJECTS AND METHOD: Salivary cortisols were collected repeatedly (n =7) over an ordinary working day (8 a.m. to 11 p.m.) in a randomly selected population of 284 men, aged 51 y. A standardized lunch was provided, and an overnight low-dose dexamethasone suppression test was performed. These measurements were correlate with the anthropometric factors—body mass index, BMI, (kg/m2), waist-to-hip ratio (WHR) and abdominal sagittal diameter; the metabolic factors—fasting insulin and glucose as well as their ratio, and triglycerides; and the haemodynamic factors—systolic and diastolic blood pressures and heart rate.
RESULTS: As reported previously two principal types of salivary cortisol secretory patterns can be singled out, one characterized by high morning cortisol levels, a normal circadian rhythm and feedback regulation (dexamethasone) along with a brisk cortisol response to lunch, and another, found in a limited number of men, characterized by low morning cortisols, the absence of a circadian rhythm, a relative resistance to dexamethasone inhibition and a poor lunch-induced cortisol response. The normal cortisol secretory pattern showed negative associations with BMI (P<0.05), WHR (P<0.01), and blood pressures (P<0.001). After stimulation by food intake, negative relationships were found with all obesity measurements, insulin, insulin/glucose ratio, triglycerides, blood pressures and heart rate (all P<0.001). These results suggest that normally regulated cortisol is associated with a favourable somatic health. In contrast, after food intake cortisol secretion, based on an abnormal cortisol secretory pattern, showed consistent positive associations with obesity measurements, insulin, glucose and insulin/glucose ratio, triglycerides, blood pressures and heart rate (all P<0.001).
CONCLUSIONS: A normal HPA axis regulation is associated with excellent health anthropometric, metabolic and haemodynamic variables, particularly visible after the physiological stimulus of food intake. This is, however, not the case in men with perturbed HPA axis function where associations in these somatic variables become exaggerated by food intake. We have previously reported that perceived stress-related cortisol is associated with abnormalities in the variables mentioned above, both with a normal and, particularly, with an abnormal function of the HPA axis. It is thus apparent that perceived stress and food intake show separate associations to somatic variables with a normally functioning HPA axis, while with an abnormal regulation of this axis both perceived stress and food intake exaggerate associations to abnormal somatic variables.
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References
Reaven GM . Role of insulin resistance in human disease Diabetes 1988 37: 1595–1607.
Björntorp P . Visceral obesity: a “civilization syndrome” Obes Res 1993 1: 206–222.
Mayo-Smith W, Hayes CW, Biller BMK, Klibanski A, Rosenthal H, Rosenthal Dl . Body fat distribution measured with CT: correlations in healthy subjects, patients with anorexia nervosa, and patients with Cushing syndrome Radiology 1989 170: 15–518.
Rebuffé-Scrive M, Krotkiewski M, Elfverson J, Björntorp P . Muscule and adipose tissue morphology and metabolism in Cushing's syndrome J Clin Endocrinol Metab 1988 67: l122–1125.
Chalew S, Nagel H, Shore S . The hypothalamic–pituitary–adrenal axis in Obesity Obes Res 1995 3: 371–382.
Mårin P, Darin N, Amemiya T, Andersson B, Jern S, Björntorp P . Cortisol secretion in relation to body fat distribution in obese premenopausal women Metabolism 1992 41:: 882–886.
Pasquali R, Cantobelli S, Casirnirri F, Capelli M, Bortoluzzi L, Flamia R, Labate AMM, Barbara L . The hypothalamic–pituitary–adrenal axis in obese women with different patterns of body fat distribution J Clin Endocrinol Metab 1993 77: 341–346.
Vining RF, McGinley RA, Maksvytis JJ, Ho KY . Salivary cortisol: a better measure of adrenal cortical function than serum cortisol Ann Clin Biochem l983 20: 329–335.
Luthold WW, Marcondes JAM, Wajchenberg BL . Salivary cortisol for the evaluation of Cushing's syndrome Clin Chim Acta 1985 l51: 33–39.
Laudat MH, Cerdas S, Fournier C, Guiban D, Guilhaume B, Luton JP . Salivary cortisol measurement: a practical approach to assess pituitary-adrenal function J Clin Endocrinol Metab 1988 66: 343–348.
Kirschbaum C, Hellhammer DH . Salivary cortisol in psychoneuroendocrine research: recent developments and applications Psychoneuroendrocinology 1994 19: 313–333.
Smyth J, Ockenfels MC, Porter L, Kirschbaum DH, Hellhammer DH, Stone AA . Stressors and mood measured on a momentary basis are associated with salivary cortisol secretion Psychoncuroendocrinology 1998 23: 353–370.
Rosmond R, Dallman MF, Björntorp P . Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and haemodynamic abnormalities J Clin Endocrinol Metab 1998 83: 1853–1859.
Rosmond R, Lapidus L, Björntorp P . The influence of occupational and social factors on obesity and body fat distribution in middle-aged men Int J Obes Relat Metab Disord l996 20: 599–607.
Rosmond K Lapidus L, Mårin P, Björntorp P . A Mental distress, obesity and body fat distribution in middle-aged men Obes Red 1996 4: 245–252.
Rosmond R, Lapidus L, Björntorp P . A comparative review of psychosocial and occupational environment in native Swedes and immigrants Scand J Soc Med 1996 24: 237–242.
Bray GA . An approach to the classification and evaluation of obesity. In Björntorp P, Brodoff BN (eds) Obesity. JB Lippincott: Philadelphia 1992 294–308.
Pouliot M-C, Després J-P, Lemieux S, Moorjani S, Bouchard C, Tremblay A, Nadeau A, Lupien PJ . Waist circumference and abdominal sagittal diameter best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men arid women Am J Cardiol 1994 73: 460–468.
Sjöström L, Lönn L, Chowdhury B, Grangård U, Lissner L, Sjöström D, Sullivan L . The sagittal diameter is a valid marker of the visceral adipose tissue volume. In Angel A, Andersson H, Bouchard C, Lau L, Leiter L, Mendelson R (eds) Progress in Obesity Research: 7. John Libbey: London 1996 pp 309–3l9.
Ljung T, Andersson B, Bengtsson B-Å, Björntorp P, Mårin P . Inhibition cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study Obes Res 1996 4: 277–282.
Römer M, Haeckel R, Bonini P, Ceriotti G, Vassault A. Solere P, Morer P . European multicentre evaluation of the ESAT 6660 J Clin Chem Clin Biochem 1990 28: 435–443.
Parker D, Liu K, Dyer AR, Giumetti D, Liao Y, Stamler J . A comparison of the random-zero and standard mercury sphygmomanometers Hypertension 1998 11: 269–272.
Sprent P . Applied Nonparametric Statistical Methods 2nd edn: Chapman & Hall: London 1993 pp217–220.
Wuttke W, Dükker E, Vaupel R, Jarry H . The neuroendocrinology of stress Stress Med 1987 3: 217–220.
Al-Damluji S, Iveson T, Thomas JM, Pendleburry DJ, Rees LH, Besser GM . Food-induced cortisol secretion is mediated by central alpha-1 adrenoreceptor modulation of pituitary ACTH secretion Clin Endocrinol 1987 26:: 629–636.
Knutsson U, Dahlgren J, Marcus C, Rosberg S, Brönnegård M, Stierna P, Albertsson-Wikland K . Circadian cortisol rhythms in healthy boys and girls relationship with age, growth, body composition, and pubertal development J Chin Endocrinol Metab l997 82: 536–540.
Dallman MF . Stress update. Adaptation of the hypothalamic–pituitary–adrenal axis to chronic stress Trends Endocrinol Metab 1993 4: 62–69.
Chrousos OP . Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture Ann NY Acad Sci 1998 851: 311–335.
Bamberger CM, Schulte HM, Chrousos GP . Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids Endocr Rev 1996 17: 245–26l.
Sapolsky RM, Krey LC, McEwen BS . The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis Endocr Rev 1986 7: 284–301.
Rosmond R, Björntorp P . Occupational status, cortisol secretory pattern and visceral obesity in middle-aged men (submitted).
Rosmond R . Low cortisol secretory levels in chronic stress Psychosom Med (in press).
Björntorp P . The regulation of adipose tissue distribution in humans Int J Obes Relat Metab Disord 1996 20: 1291–302.
Johannsson G, Mårin P, Lönn L, Ottosson M, Stenlöf K, Björntorp P, Sjöström L, Bengtsson B-Å . Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure J Clin Endocrinol Metab 1997 82: 727–734.
Mårin P, Holmäng S, Gustafsson G, Jönsson L, Kvist H, Elander A, Eldh J, Sjöström L, Holm G, Björntorp P . Androgen treatment of abdominally obese men Obes Res 1993 1: 245–251.
Yehuda R, Teicher MH, Lovengood RA, Trestman RL, Siever LJ . Circadian regulation of basal cortisol levels in posttraumatic stress disorder Ann NY Acad Sci 1994 746: 378–380.
Demitrack MA, Dale JK, Straus SE, Laue L, Listwak SJ, Kruesi MJP, Chrousos GP, Gold PW . Evidence for impaired activation of the hypothalamic–pituitary–adrenal axis in patients with chronic fatigue syndrome J Clin Endocrinol Metab 1991 73: 1224–1234.
Pruessner JC, Hellhammer DH, Kirschbaum C . Burnout, perceived stress and cortisol responses to awakening Psychosom Med 1999 6l: l97–2O4.
Crofford LJ, Pillemer Sr, Kalogeras KT . Hypothalamic–pituitary–adrenal axis perturbations in patients with fibromyalgia Arthritis Reum 1994 37: 1583–1592.
Kristenson M, Orth-Gomér K, Kucinskienë Z, Bergdahl B, Calkauskas H, Balinkyniene I, Olsson AG . Attenuated cortisol response to a standardized stress test in Lithuanian versus Swedish men: The LiVicordia Study Int J Behav Med 1998 5: 17–30.
McEwen BS . Protective and damaging effects of stress mediators New Engl J Med 1998 338: 171–9.
Rosmond R, Björntorp P . Endocrine and metabolic aberrations in men with abdominal obesity in relation to anxio-depressive infirmity Metabolism 1998 47: 1187–1193.
Brunuer EJ, Marmot MG, Nanchahal K, Shipley MJ, Stansfeld SA, Juneja M, Alberti KGMM . Social inequality in coronary risk: central obesity and the metabolic syndrome. Evidence front the Whitehall II study Diabetological 1997 40:: 1341–1349.
Rosmond R, Chagnon YC, Holm G, Chagnon M, Pérusse L, Lindell K, Carlsson B, Bouchard C, Björntorp P . A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin and dysregulation of the hypothalamic–pituitary–adrenal axis Int J Obes Relat Metab Disord 1999 23 (Suppl. 5): S32.
Rosmond R, Björntorp P . Psychiatric ill-health of women and its relationship to obesity and body fat distribution Obes Res 1998 6: 338–345.
Rosmond J, Björntorp P . Psychosocial and socio-economic factors in women and their relationship to obesity and regional body fat distribution Int J Obes Relat Metab Disord 1999 23: 138–145.
Acknowledgements
The authors thank (in alphabetic order) Christina Jonsteg, George Lappas, Katarina Romanus, Erik Tengdahl and Inga-Lill Åhs for excellent technical assistance. The study was supported by the Swedish Medical Research Council (K97-19X-00251-35A).
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Rosmond, R., Holm, G. & Björntorp, P. Food-induced cortisol secretion in relation to anthropometric, metabolic and haemodynamic variables in men. Int J Obes 24, 416–422 (2000). https://doi.org/10.1038/sj.ijo.0801173
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DOI: https://doi.org/10.1038/sj.ijo.0801173
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