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Effect of menopausal status on body composition and abdominal fat distribution

Abstract

OBJECTIVE: Preliminary studies suggest that the menopause transition is associated with deleterious changes in body composition and abdominal fat distribution. Limitations of the methodology used in these studies, however, render their conclusions controversial. Thus, the present study used radiologic imaging techniques to examine the effect of menopausal status on body composition and abdominal fat distribution.

DESIGN: Cross-sectional.

SUBJECTS: Fifty-three healthy, middle-aged, premenopausal women (mean±SD; 47±3 y) and 28 early-postmenopausal women (51±4 y).

MEASUREMENTS: Total and regional body composition by dual energy X-ray absorptiometry and abdominal fat distribution by computed tomography.

RESULTS: No differences in total body fat-free mass or appendicular skeletal muscle mass were noted between groups. In contrast, total body fat mass was 28% higher (23±7 vs 18±7 kg) and percentage fat 17% higher (35±6 vs 30±9%; both P<0.01) in postmenopausal women compared with premenopausal women. Postmenopausal women had a 49% greater intra-abdominal (88±32 vs 59±32 cm2; P<0.01) and a 22% greater abdominal subcutaneous fat area (277±93 vs 227±108 cm2; P<0.05) compared to premenopausal women. The menopause-related difference in intra-abdominal fat persisted (P<0.05) after statistical adjustment for age and total body fat mass, whereas no difference in abdominal subcutaneous fat was noted. A similar pattern of differences in total and abdominal adiposity was noted in sub-samples of pre- and postmenopausal women matched for age or fat mass.

CONCLUSION: Our data suggest that early-postmenopausal status is associated with a preferential increase in intra-abdominal fat that is independent of age and total body fat mass.

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References

  1. Poehlman ET, Toth MJ, Gardner AW . Changes in energy balance and body composition at menopause: a controlled longitudinal study Ann Intern Med 1995 123: 673–675.

    Article  CAS  Google Scholar 

  2. Björkelund C, Lissner L, Andresson S, Lapidus L, Bengtsson C . Reproductive history in relation to relative weight and fat distribution Int J Obes 1996 20: 213–219.

    Google Scholar 

  3. Lindsay R, Aitken JM, Anderson JB, Hart DM, MacDonald EB, Clarke AC . Long-term prevention of postmenopausal osteoporosis by estrogen Lancet 1976 1: 1038–1041.

    Article  CAS  Google Scholar 

  4. Heymsfield SB, Wang J, Lichtman S, Kamen Y, Kehayias J, Pierson RN . Body composition in elderly subjects: a critical appraisal of clinical methodology Am J Clin Nutr 1989 50: 1167–1175.

    Article  CAS  Google Scholar 

  5. van der Kooy K, Leenen R, Seidell JC, Deurenberg P, Droop A, Bakker CJG . Waist–hip ratio is a poor predictor of changes in visceral fat Am J Clin Nutr 1993 57: 327–333.

    Article  CAS  Google Scholar 

  6. Lemieux S, Prud'homme D, Tremblay A, Bouchard C, Després JP . Anthropometric correlates to changes in visceral adipose tissue over 7 years in women Int J Obes 1996 20: 618–624.

    CAS  Google Scholar 

  7. Toth MJ, Sites CK, Poehlman ET . Hormonal and physiological correlates of energy expenditure and substrate oxidation in middle-aged, premenopausal women J Clin Endocrinol Metab 1999 4: 2771–2775.

    Google Scholar 

  8. Heymsfield SB, Smith R, Aulet M, Bensen B, Lichtman S, Wang J, Pierson RN . Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry Am J Clin Nutr 1990 52: 214–218.

    Article  CAS  Google Scholar 

  9. Toth MJ, Gottlieb SS, Fisher ML, Poehlman ET . Skeletal muscle atrophy and peak oxygen consumption in heart failure Am J Cardiol 1997 79: 1267–1269.

    Article  CAS  Google Scholar 

  10. Toth MJ, Goran MI, Ades PA, Howard DB, Poehlman ET . Examination of data normalization procedures for expressing peak VO2 data Am J Physiol 1993 75: 2288–2292.

    CAS  Google Scholar 

  11. Tchernof A, Poehlman ET . Effects of the menopause transition on body fatness and body fat distribution Obes Res 1998 6: 246–254.

    Article  CAS  Google Scholar 

  12. Trémollieres FA, Pouilles J-M, Ribot CA . Relative influence of age and menopause on total and regional body composition changes in postmenopausal women Am J Obstet Gynecol 1996 175: 1594–1600.

    Article  Google Scholar 

  13. Svendsen OL, Hassager C, Christiansen C . Age- and menopause-associated variations in body composition and fat distribution in healthy women as measured by dual energy X-ray absorptiometry Metabolism 1995 44: 369–373.

    Article  CAS  Google Scholar 

  14. Hunter GR, Kekes-Szabo T, Treuth MS, Williams MJ, Goran MI, Pichon C . Intra-abdominal adipose tissue, physical activity and cardiovascular risk in npre- and post-menopausal women Int J Obes 1996 20: 860–865.

    CAS  Google Scholar 

  15. Zamboni M, Armellini F, Milani MP, DeMarchi M, Todesco T, Robbi R, Bergamo-Andreis IA, Bosello O . Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships Int J Obes 1992 16: 495–504.

    CAS  Google Scholar 

  16. Kontani K, Tokunaga K, Fujioka S, Kobatake T, Keno Y, Yoshida S, Simomura I, Tarui S, Matsuzawa Y . Sexual dimorphism of age-related changes in whole-body fat distribution in the obese Int J Obes 1994 18: 207–212.

    Google Scholar 

  17. Rebuffé-Scrive M, Andersson B, Olbe L, Bjorntorp P . Metabolism of adipose tissue in intraabdominal depots of nonobese men and women Metabolism 1989 38: 453–458.

    Article  Google Scholar 

  18. Kissebah AH, Krakower GR . Regional adiposity and morbidity Physiol Rev 1994 74: 761–811.

    Article  CAS  Google Scholar 

  19. Després JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C . Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease Arteriosclerosis 1990 10: 497–511.

    Article  Google Scholar 

  20. Poehlman ET, Goran MI, Gardner AW, Ades PA, Arciero PJ, Katzman-Rooks SM, Montgomery Sm, Toth MJ, Sutherland PT . Determinants of decline in resting metabolic rate in aging females Am J Physiol 1993 264: E450–E455.

    CAS  PubMed  Google Scholar 

  21. Aloia JF, McGowan DM, Vaswani AN, Ross P, Cohn SH . Relationship of menopause to skeletal and muscle mass Am J Clin Nutr 1991 53: 1378–1383.

    Article  CAS  Google Scholar 

  22. Garrow JS . Energy balance in man—an overview Am J Clin Nutr 1987 45: 1114–1119.

    Article  CAS  Google Scholar 

  23. Dahlberg E . Characterization of the cytosolic estrogen receptor in rat skeletal muscle Biochim Biophys Acta 1982 717: 65–75.

    Article  CAS  Google Scholar 

  24. Poehlman ET, Toth MJ, Ades PA, Rosen CJ . Menopause-associated changes in plasma lipids, insulin-like growth factor-1 and blood pressure: a longitudinal study Eur J Clin Invest 1997 27: 322–326.

    Article  CAS  Google Scholar 

  25. Frontera WR, Hughes VA, Lutz KJ, Evans WJ . A cross-sectional study of muscle strength and mass in 45- to 78-yr old men and women J Appl Physiol 1991 71: 644–650.

    Article  CAS  Google Scholar 

  26. Toth MJ, Gardner AW, Ades PA, Poehlman ET . Contribution of body composition and physical activity to age-related decline in peak VO2 in men and women J Appl Physiol 1994 77: 647–652.

    Article  CAS  Google Scholar 

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Acknowledgements

The authors would like to thank all the participants who volunteered their time for this study. We are grateful to Denise Defalco-McGeein, Martin Brochu and Chris Potter for their skilled assistance. This work was supported by grants from the NIH (AG-13978; M01 RR-1093252; AG-151121), the United States Department of Agriculture (96-35200-3488), General Clinical Research Center (RR-00109) and the American Federation for Aging Research. Dr Tchernof is the recipient of a postdoctoral research fellowship from the Canadian Diabetes Association.

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Correspondence to ET Poehlman.

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Toth, M., Tchernof, A., Sites, C. et al. Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes 24, 226–231 (2000). https://doi.org/10.1038/sj.ijo.0801118

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Keywords

  • menopause
  • body composition
  • body fat distribution
  • fat-free mass
  • fat mass

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