Abstract
WHEN the campaign against malaria was commenced, our knowledge,of the parasitic agent,of that disease, was practically complete, and in no essential particular has our knowledge of the mode of transmission changed since, the discovery of the anopheline-malarial cycle! But when we consider sleeping sickness the matter is Very different. Our knowledge of trypanosomes is even yet in its infancy. It has, for instance, been asserted over and over again that sexual differences exist in trypanosomes, and on this basis have been constructed developmental cycles which indeed may exist, but in proof of which the evidence hitherto adduced has been practically nil; and indeed two of the latest observers, Moore and Breihl, not only find no evidence of this sexual difference, at least in the blood, but describe two new phases of trypanosomes, viz. a so-called minute, latent form, which comes into existence mainly when the ordinary forms from one cause or another have disappeared from the peripheral circulation, and resistant cystic forms, which appear when an animal is treated with atoxyl.
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S., J. Sleeping Sickness 1 . Nature 77, 440–442 (1908). https://doi.org/10.1038/077440a0
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DOI: https://doi.org/10.1038/077440a0