Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Physiology: Coagulation of Blood


PROF. MANTEGAZZA cuts the Gordian knot of the cause of the coagulation of the blood, by attributing it to an action of the white corpuscles of the blood. Admitting Schmidt's theory of fibrin being the product of fibrinoplastin and fibrinogen, he puts forward the idea that normal plasma of the blood contains fibrinogen only, but that the white corpuscles have the power, when irritated, of emitting, or we might almost say secreting, fibrinoplastin, and thus of causing coagulation. The shedding of blood, any contact with foreign substances, are causes of irritation to the white blood corpuscles, and hence, these things become in turn causes of coagulation. In support of this theory he insists on the complete coincidence of the power of coagulation with the presence of white blood (or lymph) corpuscles; and on the fibrinoplastic properties of tissues, such as cornea, &c., which abound in cells similar at least in nature to white blood corpuscles.—(Ann. di Chim., July 1869.)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Physiology: Coagulation of Blood. Nature 1, 117 (1869).

Download citation


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing